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cyclin-dependent kinase 6
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphory...
Normal tissues
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|
||
|---|---|---|---|
| Pylorus |
100
|
||
| Thymus |
89
|
||
| Fundus of stom… |
86
|
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| Inferior gangl… |
78
|
||
| Nipple |
77
|
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| Adrenal cortex |
76
|
Compounds
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|
||
|---|---|---|---|
| Noc 18 |
100
|
||
| Zinc Powder Or… |
92
|
||
| Methylnitronit… |
91
|
||
| Camptothecin A… |
91
|
||
| Bpde |
87
|
||
| Ethionamide |
86
|
Diseases
|
|
||
|---|---|---|---|
| Anaplastic ast… |
100
|
||
| Multiple scler… |
78
|
||
| Anogenital hum… |
77
|
||
| Astrocytoma |
77
|
||
| Patau's syndro… |
75
|
||
| Acute myeloid … |
75
|
 Individual Studies |
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|---|---|
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Homo sapiens
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RNA Expression
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High expression of active CDK6 in the cytoplasm of CD8 memory cells favors rapid division.
Authors: Henrique Veiga-Fernandes, Benedita Rocha
Nature immunology 2004 Jan -
Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6.
Authors: Marcos Malumbres, Rocío Sotillo, David Santamaría, Javier Galán, Ana Cerezo, Sagrario Ortega, Pierre Dubus, Mariano Barbacid
Cell 2004 Aug 20
Thought leaders and organizations working on research involving CDK6.
- Mariano Barbacid
- Marcos Malumbres
- Rebecca Jones
- Paula L Miliani de Marval
- Yue Xiong
- Centro Nacional de Investigaciones Oncológicas
- University of Tokyo
- North Carolina State University
- Institut National de la Santé et de la Recherche Médicale U591
- Université Libre de Bruxelles
