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cytidine deaminase

This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias. [provided by RefSeq]

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Data Correlations | 1,078 studies

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Tissues category icon Normal tissues
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Mucosa of mouth 100 100
Colon 93 93
Esophagus 88 88
Trigeminal ganglion 85 85
Cecum 84 84
Duodenum 82 82
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Compounds category icon Compounds
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Oxymetholone 100 100
Taxotere 96 96
Gemcitabine 94 94
Decitabine 91 91
Triferric Doxorubici… 90 90
Hydrochloric Acid 88 88
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Diseases category icon Diseases
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Abdominal aortic ane… 100 100
Pre B-cell acute lym… 99 99
Common acute lymphob… 99 99
Acute biphenotypic l… 94 94
Adenocarcinoma of lu… 93 93
Septicemia due to st… 93 93
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Individual Studies

  • 5-aza-dC treated glioblastoma cultures

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    Glioblastoma, the most aggressive and least treatable form of malignant glioma, is the most common human brain tumor. Although many regions of allelic loss occur in glioblastomas, relatively few tumor suppressor genes have been found mutated at such loci. To address the possibility that epigenetic a…

    Authors: Mueller WC, Louis DN

    Organization: Charité Universitätsmedizin Berlin Neuro…
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Associated Researchers

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Thought leaders and organizations working on research involving CDA.

View All Author iconAuthors
  • Pawel Jaruga
  • Miral Dizdaroglu
  • Jason Micklefield
  • Hermann Heimpel
  • Klaus Schwarz
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • GlaxoSmithKline
  • Ottawa Hospital Research Institute
  • University of British Columbia
  • Swiss Group for Clinical Cancer Research
  • Maastricht University Medical Center
View All Affiliations icon Organizations
  • National Institute of Standards and Technology
  • University of Ulm
  • Tel Aviv University
  • Medical University of Lodz
  • University of Manchester

Clinical Trials | 38 trials

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Community

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