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CD8b molecule
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants enco...
Diseases
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|---|---|---|---|
| Streptococcal pneumo… |
100
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| Neoplasm of thymus |
93
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| IgA myeloma |
88
|
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| IgG myeloma |
77
|
||
| Asymptomatic human i… |
72
|
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| Toxic epidermal necr… |
71
|
Gene perturbations
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|---|---|---|---|
| BCL6 gene |
100
|
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| PIGA gene |
96
|
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| AICDA gene |
93
|
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| LRP5 gene |
89
|
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| MAP2K1 gene |
84
|
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| CD86 gene |
83
|
Compounds
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|
||
|---|---|---|---|
| Ferulic acid |
100
|
||
| Dimethylnitrosamine |
97
|
||
| Sulfamethoxazole |
95
|
||
| Hepatitis C protein … |
93
|
||
| Urethane |
87
|
||
| Penicillin G, Benzat… |
80
|
 Individual Studies |
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|---|---|
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Mus musculus
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RNA Expression
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Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZR.
Authors: Ivan Bilic, Christina Koesters, Bernd Unger, Masayuki Sekimata, Arnulf Hertweck, Romana Maschek, Christopher B Wilson, Wilfried Ellmeier
Nature immunology 2006 Apr -
The zinc-finger protein MAZR is part of the transcription factor network that controls the CD4 versus CD8 lineage fate of double-positive thymocytes.
Authors: Shinya Sakaguchi, Matthias Hombauer, Ivan Bilic, Yoshinori Naoe, Alexandra Schebesta, Ichiro Taniuchi, Wilfried Ellmeier
Nature immunology 2010 May
Thought leaders and organizations working on research involving CD8B.
- Medical University of Vienna
- University of Florida
- University of Toronto
- University of California
- National Cancer Institute
