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CD8a molecule

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a corepressor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains, or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain isoforms. Multiple transcript variants encoding different is...

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Data Correlations | 976 studies

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Tissues category icon Normal tissues
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Mesenteric lymph nod… 100 100
Peripheral blood mon… 99 99
Thymus 98 98
T lymphocyte 96 96
Cardia of stomach 95 95
Trigeminal ganglion 92 92
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Compounds category icon Compounds
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Enterotoxin 100 100
Cerivastatin 94 94
Neurokinin B 92 92
Transforming Growth … 90 90
Pralidoxime Chloride 87 87
Ferulic Acid 86 86
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Diseases category icon Diseases
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Neoplasm of thymus 100 100
Acute lymphoid leuke… 88 88
Complication of tran… 87 87
Asymptomatic human i… 82 82
Melanoma 81 81
Bordetella 79 79
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Individual Studies

  • Effect of in-vivo intrapulmonary administration of LTK63

    score: 100100 | Mus musculus Mus musculus | RNA Expression   RNA Expression

    Transcription profiling of mouse lung following in-vivo intrapulmonary administration of LTK63, a non-toxic mutant of E. coli heat labile enterotoxin.

    Source: NextBio Library/Pharmacology and Toxicology

  • Gene Expression of Human Lymphocytes Used For ACT of Metastatic Melanoma

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    Recent reports have detailed the efficacy of the adoptive cell transfer (ACT) of autologous anti-tumor lymphocytes for the treatment of patients with melanoma refractory to standard therapy. Here we report the microarray analysis of tumor infiltrating lymphocytes (TIL) generated from twenty-eight me…

    Organization: National Institutes of Health Surgery Br…
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Associated Researchers

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Thought leaders and organizations working on research involving CD8A.

View All Author iconAuthors
  • E John Wherry
  • Rafi Ahmed
  • Maries van den Broek
  • Lionel Feigenbaum
  • Shawn D Blackburn
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • National Institute of Allergy and Infectious Diseases (NIAID)
  • GlaxoSmithKline
  • Fred Hutchinson Cancer Research Center
  • Beckman Research Institute
  • National Cancer Institute (NCI)
View All Affiliations icon Organizations
  • National Cancer Institute
  • Yale University School of Medicine
  • University of Pennsylvania School of Medicine
  • Wistar Institute
  • Fox Chase Cancer Center

Clinical Trials | 50 trials

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Community

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