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CD36 molecule (thrombospondin receptor)
The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platel...
Normal tissues
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|
||
|---|---|---|---|
| Adipose tissue |
100
|
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| Pericardium |
95
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| Superior vena cava |
93
|
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| Synovial membrane |
88
|
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| Epidermis |
85
|
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| Vulva |
85
|
Compounds
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|
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|---|---|---|---|
| Magnesium Ion |
100
|
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| Zinc00154653 |
96
|
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| Naphthalene |
93
|
||
| Salmonella Typhi End… |
92
|
||
| Nafenopin |
92
|
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| Rosiglitazone |
89
|
Diseases
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|
||
|---|---|---|---|
| Pterygium |
100
|
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| Coronary arterioscle… |
99
|
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| Malaria |
99
|
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| Thrombocytopenia |
99
|
||
| Adenocarcinoma of br… |
82
|
||
| Lobular carcinoma |
73
|
 Individual Studies |
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|---|---|
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Mus musculus
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Mutations/Phenotypic
RNA Expression
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Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension.
Authors: Michal Pravenec, Paul C Churchill, Monique C Churchill, Ondrej Viklicky, Ludmila Kazdova, Timothy J Aitman, Enrico Petretto, Norbert Hubner, Caroline A Wallace, Heike Zimdahl,…
Nature genetics 2008 Aug -
CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer.
Authors: Cameron R Stewart, Lynda M Stuart, Kim Wilkinson, Janine M van Gils, Jiusheng Deng, Annett Halle, Katey J Rayner, Laurent Boyer, Ruiqin Zhong, William A Frazier,…
Nature immunology 2010 Feb
Thought leaders and organizations working on research involving CD36.
- National Institutes of Health Clinical Center (CC)
- University Health Network, Toronto
- TNO Quality of Life
- St Stephens Aids Trust
- National Heart, Lung, and Blood Institute (NHLBI)
- University of Alberta
- Rockefeller University
- Cleveland Clinic Foundation
- Harvard Medical School
- Institute of Physiology and Center for Applied Genomics
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Identification of Donors of CD36-Deficient Platelets Among Japanese Individuals on the NIH Campus
conditions: Thrombocytopenia
interventions: none
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The Cytoadherence in Pediatric Malaria (CPM) Study
conditions: Plasmodium Falciparum Malaria
interventions: none
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Effect of cocoa powder on the modulation of inflammatory biomarkers in patients at high risk of cardiovascular disease [Cardiovascular disease risk]
American journal. - October 20, 2009 -
[Supplement: The Emerging Interplay among Muscle Mitochondrial Function, Nutrition, and Disease] Regulation of skeletal muscle mitochondrial fatty acid metabolism in lean and obese individuals
American journal. - January 05, 2009
