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caspase 9, apoptosis-related cysteine peptidase
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspase APAF1; this step is thought to be one of the earliest in the caspase activation cascade. Alternative splicing results in two transcript variants which encode different isoforms. [provided by RefSeq]
Normal tissues
|
|
||
|---|---|---|---|
| Adrenal cortex |
100
|
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| Adrenal gland |
76
|
||
| Thyroid gland |
75
|
||
| Pericardium |
73
|
||
| Medulla of kidney |
71
|
||
| Globus pallidus |
71
|
Compounds
|
|
||
|---|---|---|---|
| Ethambutol |
100
|
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| Methacycline |
100
|
||
| Staurosporine |
96
|
||
| Phorbol Ester |
95
|
||
| Quipazine |
93
|
||
| Fipexide |
90
|
Diseases
|
|
||
|---|---|---|---|
| Abdominothoracic neu… |
100
|
||
| Adrenal neuroblastom… |
100
|
||
| Adrenal carcinoma |
100
|
||
| Compression injury o… |
99
|
||
| Cerebral malaria |
96
|
||
| Scott syndrome |
95
|
 Individual Studies |
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|---|---|
|
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Homo sapiens
|
RNA Expression
Mus musculus
|
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Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling.
Authors: Zhaoyu Jin, Yun Li, Robert Pitti, David Lawrence, Victoria C Pham, Jennie R Lill, Avi Ashkenazi
Cell 2009 May 15 -
The protein kinase DYRK1A regulates caspase-9-mediated apoptosis during retina development.
Authors: Ariadna Laguna, Sergi Aranda, María José Barallobre, Rima Barhoum, Eduardo Fernández, Vassiliki Fotaki, Jean Maurice Delabar, Susana de la Luna, Pedro de la Villa, Maria L Arbonés
Developmental cell 2008 Dec
Thought leaders and organizations working on research involving CASP9.
- University Health Network, Toronto
- Maier, Lisa, M.D.
- Washington University School of Medicine
- University of Dundee
- Princeton University
- Burnham Institute for Medical Research
- Walter and Eliza Hall Institute of Medical Research
- University of Texas M.D. Anderson Cancer Center
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Apoptosis and Hepatitis B: The Role of Apoptosis in Patients Who Are HBeAg Negative
conditions: Hepatitis B
interventions: none
-
A Phase I Study Of Thymoglobulin In Patients With Relapsed Or Refractory Multiple Myeloma
conditions: Relapsed or Refractory Multiple Myeloma
interventions: thymoglobulin
Community
Suresh G. Joshi
Surgical Infections & Bacterial Pathogenesis
Drexel University College of Medicine
Imtiaz Siddiqui
-
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