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caspase 3, apoptosis-related cysteine peptidase

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzhei...

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Data Correlations | 1,618 studies

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Tissues category icon Normal tissues
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Vomeronasal organ 100 100
Cecum 97 97
Femur 93 93
Mesenteric lymph nod… 91 91
Synovial membrane of… 88 88
Viscerocranial mucos… 85 85
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Compounds category icon Compounds
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Azaperone 100 100
Bacteroides Fragilis… 90 90
Dibenzazepine 90 90
Immunoglobulins 80 80
Stanozolol 77 77
Methylbenzylnitrosam… 77 77
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Diseases category icon Diseases
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Idiopathic thrombocy… 100 100
Other specified gast… 95 95
Lymphocytic choriome… 95 95
Infection due to Bac… 93 93
Nerve injury 92 92
Adenocarcinoma of es… 91 91
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Individual Studies

  • Effect of formula feeding and hypoxia on Necrotizing Enterocolitis development

    score: 100100 | Rattus norvegicus Rattus norvegicus | RNA Expression   RNA Expression

    Necrotizing Enterocolitis (NEC) is an inflammation causing injury to the bowel in newborns. This project uses a rodent model that mimics the intestinal pathological changes seen in NEC to study the effect of formula feeding and hypoxia on NEC development.

    Authors: Upperman J

    Organization: Children's National Medical Center Child…

  • Hippocampus and cerebral cortex from mice deficient in Cox-1 or Cox-2

    score: 100100 | Mus musculus Mus musculus | RNA Expression   RNA Expression

    We analyzed the overall gene expression from the cortex and hippocampus of COX-1 +/+, COX-1 -/-, COX-2 +/+, COX-2 -/-, and COX-2 +/-.

    Authors: Toscano D Christopher, Bosetti Francesca, Prabhu V Vinaykumar et al.

    Organization: National Institutes of Health National I…
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Associated Researchers

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Thought leaders and organizations working on research involving CASP3.

View All Author iconAuthors
  • Sandra Ussat
  • Vivek M Rangnekar
  • Bram J van Raam
  • C-W Kim
  • Yu-Min Lin
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Mayo Clinic
  • University of Connecticut Health Center
  • Robert H. Lurie Cancer Center
  • Case Comprehensive Cancer Center
  • University Medical Centre Groningen
View All Affiliations icon Organizations
  • Washington University School of Medicine
  • Faculté de Médecine et Université René Descartes Paris V
  • Dana-Farber Cancer Institute
  • Northwestern University
  • University of Minnesota

Clinical Trials | 34 trials

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Community

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