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coactivator-associated arginine methyltransferase 1
Protein arginine N-methyltransferases, such as CARM1, catalyze the transfer of a methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins to form methylated arginine derivatives and S-adenosyl-L-homocysteine. Protein arginine methylation has been implicated in signal transduction, metabolism of nascent pre-RNA, and transcriptional activation (Frankel et al., 2002 [PubMed 11724789]).[supplied by OMIM]
Normal tissues
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| Thyroid gland |
100
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| Mucosa of mouth |
97
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| Pituitary gland |
95
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| Trigeminal ganglion |
94
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| Adrenal gland |
92
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| Set of pancreatic is… |
92
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Compounds
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| Nimetazepam |
100
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| Carbetapentane |
92
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| Tropisetron |
89
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| Pepstatin |
89
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| Un1150 |
84
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| Etodolac |
80
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Diseases
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| Azoospermia |
100
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| N1 |
99
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| Sjogren's syndrome |
98
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| Effects of heat |
98
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| Rhinovirus infection |
97
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| Toxic epidermal necr… |
97
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 Individual Studies |
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Mus musculus
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RNA Expression
Rattus norvegicus
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The arginine methyltransferase CARM1 regulates the coupling of transcription and mRNA processing.
Authors: Donghang Cheng, Jocelyn Côté, Salam Shaaban, Mark T Bedford
Molecular cell 2007 Jan 12 -
Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53.
Authors: Woojin An, Jaehoon Kim, Robert G Roeder
Cell 2004 Jun 11
Thought leaders and organizations working on research involving CARM1.
- University of Texas M.D. Anderson Cancer Center
- University of Cambridge
- University of Zurich
- University of Massachusetts Medical School
- Institute of Genetics and Developmental Biology
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Epigenetic Mechanisms
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