syndrome including peptic ulcer of the lower esophagus, often with stricture, due to the presence of columnar lined epithelium, which may contain functional mucous cells, parietal cells, or chief cells in the esophagus instead of normal squamous cell epithelium; sometimes pre-malignant, followed by esophageal adenocarcinoma.

Data Correlations | 3 studies

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Genes	Score
SULT1C2	100
LIPF	96
FABP1	94
TFF1	94
TFF3	92
TSPAN8	92

View Top Genes

Biogroups	Score
I8 - chymotrypsin/elastase inhibit…	100
Sulphotransferase	100
I47 - latexin	99
All Peptidase Inhibitors	98
Alpha/beta hydrolase fold-1	98
Arginine C Pathway	98

View Top Biogroups

Individual Studies

Barrett's esophagus - metaplasia progression to adenocarcinoma Homo sapiens |   RNA Expression Samples representative of the normal esophageal epithelium (N), Barrett’s esophagus (B) and esophageal adenocarcinomas (ADC) were compared. Authors: Kimchi Eric, Park James, Darga Thomas et al. Organization: The University of Chicago Radiation and …

Barrett's normal and affected esophagus versus small intestine comparison Homo sapiens |   RNA Expression Barrett's esophagus is a premalignant condition whereby the normal stratified squamous esophageal epithelium undergoes a transdifferentiation program resulting in a simple columnar epithelium reminiscent of the small intestine. Authors: Stairs B Douglas, Silberg G Debra, Tobias W John et al. Organization: University of Pennsylvania Medicine-Gast…

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Literature | 1,070 results

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• Barrett's oesophagus.

  Authors: Nicholas J Shaheen, Joel E Richter

  Lancet 2009 Mar 7

• Association of adiponectin multimers with Barrett's oesophagus.

  Authors: J H Rubenstein, J Y Kao, R D Madanick, M Zhang, M Wang, M B Spacek, J L Donovan, S D Bright, N J Shaheen

  Gut 2009 Dec

Associated Researchers

Thought leaders and organizations working on research involving Barrett's oesophagus.

View All Authors

• R C Fitzgerald
• G Rumore
• G Block
• T R Levin
• J J G H M Bergman

View All Clinical Trials Sponsors

• Medical Research Council
• Nantes University Hospital
• Axcan Pharma
• UMC Utrecht
• Janssen-Cilag Pty Ltd

View All Organizations

• Hutchison-MRC Research Centre
• Royal Free and University College Medical School
• University of North Carolina School of Medicine
• VA Medical Center 111-D
• Boston University Medical Center

Clinical Trials | 8 trials

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• Studying Genes for Barrett's Esophagus in Brothers and Sisters

  conditions: Esophageal Cancer ; Precancerous/Nonmalignant Condition

  interventions: comparative genomic hybridization ; genetic linkage analysis ; laboratory biomarker analysis ; questionnaire administration ; study of high risk factors

   

• Functional and Molecular Characterisation of Oesophageal Distal Epithelium: Correlations With Acid and Non Acid Reflux

  conditions: Gastroesophageal Reflux

  interventions: none

   

News | 4 stories

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• [Seminar] Barrett's oesophagus

  Lancet. - March 05, 2009

• Further Research Urged By Barrett's Oesophagus Campaign

  Medical News Today. - March 05, 2009

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