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bromodomain containing 4
The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described. [provided by RefSeq]
Normal tissues
|
|
||
|---|---|---|---|
| Nipple |
100
|
||
| Pylorus |
86
|
||
| Fundus of stomach |
84
|
||
| Vermis of cerebellum |
79
|
||
| Coronary artery |
79
|
||
| Subdivision of subst… |
78
|
Compounds
|
|
||
|---|---|---|---|
| Naphthalan |
100
|
||
| Magnesium Valproate |
93
|
||
| Strontium |
83
|
||
| Double-stranded Dna |
82
|
||
| Canrenoic Acid |
79
|
||
| Cromolyn |
76
|
Diseases
|
|
||
|---|---|---|---|
| Lethal midline granu… |
100
|
||
| Streptococcus pyogen… |
65
|
||
| Radiation injury |
58
|
||
| Starvation |
57
|
||
| Food deprivation |
50
|
||
| Chagas' disease |
50
|
 Individual Studies |
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|---|---|
|
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Homo sapiens
|
Mutations/Phenotypic
RNA Expression
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Interaction of the bovine papillomavirus E2 protein with Brd4 tethers the viral DNA to host mitotic chromosomes.
Authors: Jianxin You, Jennie L Croyle, Akiko Nishimura, Keiko Ozato, Peter M Howley
Cell 2004 Apr 30 -
Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4.
Authors: Zhiyuan Yang, Jasper H N Yik, Ruichuan Chen, Nanhai He, Moon Kyoo Jang, Keiko Ozato, Qiang Zhou
Molecular cell 2005 Aug 19
Thought leaders and organizations working on research involving BRD4.
- Harvard Medical School
- University of California
- Laboratory of Viral Diseases
- National Institute of Child Health and Human Development
- National Cancer Institute
