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breast cancer 1, early onset
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited...
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|---|---|---|---|
| Zygote |
100
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| Femur |
88
|
||
| Appendix |
73
|
||
| B lymphoblast |
67
|
||
| Caudate nucleus |
67
|
||
| Vulva |
66
|
|
|
|
||
|---|---|---|---|
| Conjugated Linoleic … |
100
|
||
| Vinblastine |
77
|
||
| Tiratricol |
76
|
||
| Dimenhydrinate |
76
|
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| Sc 560 |
74
|
||
| Transferrin |
71
|
Individual Studies |
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Authors: Joanna R Morris, Chris Boutell, Melanie Keppler, Ruth Densham, Daniel Weekes, Amin Alamshah, Laura Butler, Yaron Galanty, Laurent Pangon, Tai Kiuchi,…
Nature 2009 Dec 17Authors: Elgene Lim, François Vaillant, Di Wu, Natasha C Forrest, Bhupinder Pal, Adam H Hart, Marie-Liesse Asselin-Labat, David E Gyorki, Teresa Ward, Audrey Partanen,…
Nature medicine 2009 AugThought leaders and organizations working on research involving BRCA1.
conditions: Ovarian Neoplasms ; BRCA1 Protein ; BRCA2 Protein
interventions: KU-0059436 (AZD2281)(PARP inhibitor)
conditions: Breast Cancer
interventions: counseling intervention