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brain-derived neurotrophic factor

The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq]

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Data Correlations | 1,111 studies

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Tissues category icon Normal tissues
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Great saphenous vein 100 100
Hemisphere of cerebe… 91 91
Superior vena cava 88 88
Vermis of cerebellum 79 79
Vestibular nuclear c… 74 74
Medulla oblongata 71 71
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Compounds category icon Compounds
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Potassium Chloride (… 100 100
Aminophylline 92 92
Kainic Acid 84 84
Nabumetone 81 81
Collagen 80 80
Fluoxetine 80 80
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Diseases category icon Diseases
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Eating disorder 100 100
Obsessive compulsive… 100 100
Central alveolar hyp… 98 98
Organic memory impai… 97 97
Deprivation of water 88 88
Not getting enough s… 69 69
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Individual Studies

  • OMIM - Disease of brain

    score: 100100 | Homo sapiens Homo sapiens | Mutations/Phenotypic   Mutations/Phenotypic

    This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories.

    Source: NextBio Library/Mutation and Phenotypic data

  • Study of activity-regulated genes in mouse primary cultured neurons

    score: 100100 | Mus musculus Mus musculus | RNA Expression   RNA Expression

    This SuperSeries is composed of the following subset Series: GSE11256: KCl depolarization-regulated genes in mouse cortical neurons GSE11258: Npas4-regulated genes in mouse hippocampal neurons

    Organization: Children' Hospital/Harvard Medical Schoo…
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Associated Researchers

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Thought leaders and organizations working on research involving BDNF.

View All Author iconAuthors
  • Bai Lu
  • Michael E Greenberg
  • Elizabeth J Hong
  • Yuanyuan Ji
  • Freda D Miller
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Massachusetts General Hospital
  • Hospital de Clinicas de Porto Alegre
  • National Institute of Neurological Disorders and Stroke (NINDS)
  • Weill Medical College of Cornell University
  • Mount Sinai School of Medicine
View All Affiliations icon Organizations
  • University of California
  • Hospital for Sick Children
  • National Institute of Mental Health
  • National Institute of Child Health and Human Development
  • University of Wisconsin

News | 9 stories

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