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breakpoint cluster region
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found...
Normal tissues
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|
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|---|---|---|---|
| Caudate nucleus |
100
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| Putamen |
90
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| Adrenal gland |
83
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| Mucosa of mouth |
78
|
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| Superior cervical ga… |
77
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| Thyroid gland |
77
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Compounds
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|
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|---|---|---|---|
| Sulmazole |
100
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| Tadjakonine |
97
|
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| Calcimycin |
89
|
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| Boldine |
88
|
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| Dihydroergotamine |
88
|
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| Canrenoic Acid |
87
|
 Individual Studies |
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|---|---|
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Homo sapiens
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Mutations/Phenotypic
RNA Expression
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HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species.
Authors: Melania Capasso, Mandeep K Bhamrah, Tom Henley, Robert S Boyd, Claudia Langlais, Kelvin Cain, David Dinsdale, Karen Pulford, Mahmood Khan, Boris Musset,…
Nature immunology 2010 Mar -
Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors.
Authors: Jianming Zhang, Francisco J Adrián, Wolfgang Jahnke, Sandra W Cowan-Jacob, Allen G Li, Roxana E Iacob, Taebo Sim, John Powers, Christine Dierks, Fangxian Sun,…
Nature 2010 Jan 28
Thought leaders and organizations working on research involving BCR.
- M.D. Anderson Cancer Center
- Fred Hutchinson Cancer Research Center
- Gruppo Italiano Malattie EMatologiche dell'Adulto
- National Heart, Lung, and Blood Institute (NHLBI)
- Cancer and Leukemia Group B
- University of Texas M.D. Anderson Cancer Center
- University of Pennsylvania School of Medicine
- Dana-Farber Cancer Institute
- National Institute of Allergy and Infectious Diseases
- London Research Institute
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Study Using Vaccination With Heat Shock Protein 70 (HSP70) for the Treatment of CML in Chronic Phase
conditions: Leukemia,Myeloid, Chronic ; Leukemia,Myeloid,Philadelphia-Positive
interventions: Heat Shock Protein 70 HSP70
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STA-9090 for Treatment of AML, CML, MDS and Myeloproliferative Disorders
conditions: AML ; CML ; MDS ; Myeloproliferative Disorders
interventions: STA-9090
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Nationwide Children's Hospital chosen as a BCR for TCGA
News-Medical. - December 23, 2009 -
ARIAD Receives Orphan Drug Designations For Its Investigational Pan BCR-ABL Inhibitor, AP24534, In Chronic Myeloid Leukemia
Medical News Today. - March 03, 2010
Community
PhD Candidate
University of Minnesota
Ass. Professor
University of Belgrade, Faculty of Special Education and Rehabilitation
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