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butyrylcholinesterase

Mutant alleles at the BCHE locus are responsible for suxamethonium sensitivity. Homozygous persons sustain prolonged apnea after administration of the muscle relaxant suxamethonium in connection with surgical anesthesia. The activity of pseudocholinesterase in the serum is low and its substrate behavior is atypical. In the absence of the relaxant, the homozygote is at no known disadvantage. [provided by RefSeq]

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Data Correlations | 905 studies

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Tissues category icon Normal tissues
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Myometrium 100 100
Uterine tube 95 95
Cervix of uterus 92 92
Pericardium 91 91
Segment of venous tr… 86 86
Vagina 86 86
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Compounds category icon Compounds
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C07400 100 100
Echodide 100 100
Mylaxen 100 100
Rivastigmine 100 100
Isoflurophate 99 99
Physostigmine 99 99
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Diseases category icon Diseases
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Roberts-SC phocomeli… 100 100
Gastrointestinal str… 72 72
Anomaly of chromosom… 72 72
Hepatocellular dyspl… 65 65
Melanoma of skin 63 63
Neurilemmoma 62 62
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Individual Studies

  • Drug target sets for approved compounds

    score: 100100 | Homo sapiens Homo sapiens | Therapeutic   Therapeutic

    The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.

    Authors: David S Wishart, Craig Knox, An Chi Guo et al.

    Organization: Department of Computing Science, Univers…
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Associated Researchers

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Thought leaders and organizations working on research involving BCHE.

View All Author iconAuthors
  • Eleidi A Chautard-Freire-Maia
  • Ricardo L R Souza
  • Liya R Mikami
  • Oksana Lockridge
  • K P Ng
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • National Institute on Aging (NIA)
  • Baxter Healthcare Corporation
  • Voyager Pharmaceutical Corporation
  • Wyeth
  • Pfizer
View All Affiliations icon Organizations
  • Federal University of Paraná
  • Chung Shan Medical University Hospital
  • Queen Elizabeth Hospital
  • Sun Yat-sen University
  • Douglas Hospital Research Centre

Clinical Trials | 64 trials

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Community

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