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Rho guanine nucleotide exchange factor (GEF) 11

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq]

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Data Correlations | 1,036 studies

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Diseases category icon Diseases
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Disease due to Hanta… 100 100
Morphea 100 100
Squamous cell carcin… 97 97
Chronic obstructive … 97 97
Renal interstitial f… 89 89
Carcinoid tumor (exc… 86 86
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Geneticperturbations category icon Gene perturbations
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STAT3 gene 100 100
PRNP gene 87 87
IRF6 gene 84 84
TNFRSF6B gene 83 83
CXCL1 gene 79 79
WNT1 gene 77 77
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Compounds category icon Compounds
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Flavoxate 100 100
Fazarabine 92 92
Florfenicol 91 91
Dyphylline 90 90
Cyclacillin 86 86
Cromolyn Sodium 86 86
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Individual Studies

  • Changes in Toxoplasma gondii infected human cells

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    Cells infected with the intracellular protozoan parasite Toxoplasma gondii undergo upregulation of pro-inflammatory cytokines, organelle redistribution, and protection from apoptosis. To examine the molecular basis of these and other changes, gene expression profiles of human foreskin fibroblasts in…

    Authors: Blader Ira

    Organization: Stanford Microarray Database (SMD) Stanf…

  • HeLa cells synchronized then released from S and mitosis phases

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    HeLa S3 cells were synchronized by three different methods (double thymidine block, thymidine-nocodazole block or mitotic shake-off)in five independent time courses.

    Authors: Whitfield Michael, Demeter Janos

    Organization: Stanford Microarray Database (SMD) Stanf…
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Associated Researchers

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Thought leaders and organizations working on research involving ARHGEF11.

View All Author iconAuthors
  • Kirsten Harvey
  • James H Meador-Woodruff
  • Robert J Harvey
  • Francesco Ferraro
  • Jayashree Banerjee
View All Affiliations icon Organizations
  • Thomas Jefferson University
  • Australian National University
  • University of Heidelberg
  • University of Connecticut Health Center
  • National Institute of Diabetes and Digestive and Kidney Diseases

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