APOE - NextBio

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Search Term: APOE (gene)

Overview

apolipoprotein E

Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron ...

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Data Correlations | 1,652 studies

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Normal tissues

Score

Adrenal gland

100

Cecum

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Compounds

Score

Cyclazosin

100

Nifenazone (jan)

Ehna Hc

Cytarabine

Cardiotoxin

Nsc35679

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Diseases

Score

Sea-blue histiocyte …

100

Hyperlipoproteinemia

100

Age related macular …

Alzheimer's disease

Myocardial infarctio…

Transection of spina…

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Individual Studies
OMIM - Blood cell disorder score: 100 \| Homo sapiens \| Mutations/Phenotypic This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories. Source: NextBio Library/Mutation and Phenotypic data	Oocytes resulting in early or late cleaving embryos score: 100 \| Homo sapiens \| RNA Expression Besides the established selection criteria based on embryo morphology and blastomere number, new parameters for embryo viability are needed to improve the clinical outcome of in vitro fertilization (IVF) and more particular of elective single embryo transfer (eSET). The aim of the study was to analy… Authors: van Montfoort Aafke, Geraedts Joep, Dumoulin John et al. Organization: Academic hospital Maastricht Obstetrics …

Individual Studies

OMIM - Blood cell disorder

score: 100 | Homo sapiens | Mutations/Phenotypic

This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories.

Source: NextBio Library/Mutation and Phenotypic data

Oocytes resulting in early or late cleaving embryos

score: 100 | Homo sapiens | RNA Expression

Besides the established selection criteria based on embryo morphology and blastomere number, new parameters for embryo viability are needed to improve the clinical outcome of in vitro fertilization (IVF) and more particular of elective single embryo transfer (eSET). The aim of the study was to analy…

Authors: van Montfoort Aafke, Geraedts Joep, Dumoulin John et al.

Organization: Academic hospital Maastricht Obstetrics …