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amyloid P component, serum

The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo. [provided by RefSeq]

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Data Correlations | 512 studies

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Tissues category icon Normal tissues
Score Help
Set of pancreatic is… 100 100
Fetal structure 99 99
Superior cervical ga… 95 95
Fundus of stomach 94 94
Liver 91 91
Thyroid gland 90 90
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Compounds category icon Compounds
Score Help
Oncostatin M 100 100
Mycitracin Triple An… 99 99
Ceruletide 98 98
Trovafloxacin 89 89
Trichlorofluorometha… 88 88
Temafloxacin 86 86
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Diseases category icon Diseases
Score Help
Secondary amyloidosi… 100 100
Liver carcinoma 54 54
Hepatitis B 49 49
Metabolic syndrome X 46 46
Neurilemmoma 45 45
High fat diet 42 42
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Individual Studies

  • OMIM - Amyloidosis

    score: 100100 | Homo sapiens Homo sapiens | Mutations/Phenotypic   Mutations/Phenotypic

    This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories.

    Source: NextBio Library/Mutation and Phenotypic data

  • Cytokine treatment in conditional Socs3 knockout mice

    score: 100100 | Mus musculus Mus musculus | RNA Expression   RNA Expression

    Members of the suppressor of cytokine signaling (SOCS) family are potentially key physiological negative regulators of interleukin-6 (IL-6) signaling. To examine whether SOCS3 is involved in regulating this signaling, we have used conditional gene targeting to generate mice lacking Socs3 in the live…

    Authors: Wormald S, Croker B, Hilton D

    Organization: The Walter and Eliza Hall Institute Canc…
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Associated Researchers

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Thought leaders and organizations working on research involving APCS.

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  • AndrĂ© Veillette
  • Pamela L Schwartzberg
  • David O Morgan
  • Mark B Pepys
  • Peter K Jackson
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • National Cancer Institute (NCI)
  • Mayo Clinic
  • CONKO-Studiengruppe
  • Hadassah Medical Organization
  • Dendreon
View All Affiliations icon Organizations
  • University of California
  • National Institute of Allergy and Infectious Diseases
  • Clinical Research Institute of MontrĂ©al
  • Harvard Medical School
  • Garvan Institute of Medical Research

Clinical Trials | 101 trials

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News | 17 stories

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Community

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