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amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expre...
Normal tissues
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| Ganglion of cranial … |
100
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| Substantia nigra |
99
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| Vestibular nuclear c… |
94
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| Subthalamic nucleus |
94
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| Set of cerebellar pe… |
93
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| Ventral tegmental ar… |
93
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Compounds
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| Broad-spectrum Ultra… |
100
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| Tyloxapol |
91
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| Immunoglobulins, E |
70
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| Electric Fields |
63
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| Cefixime |
58
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| Pentam 300 (as Iseth… |
56
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 Individual Studies |
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Homo sapiens
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RNA Expression
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A TAG1-APP signalling pathway through Fe65 negatively modulates neurogenesis.
Authors: Quan-Hong Ma, Toshitaka Futagawa, Wu-Lin Yang, Xiao-Dan Jiang, Li Zeng, Yasuo Takeda, Ru-Xiang Xu, Dominique Bagnard, Melitta Schachner, Andrew J Furley,…
Nature cell biology 2008 Mar -
Structural and functional characterization of a novel FE65 protein product up-regulated in cognitively impaired FE65 knockout mice.
Authors: Bethany H Cool, Galynn Zitnik, George M Martin, Qubai Hu
Journal of neurochemistry 2010 Jan
Thought leaders and organizations working on research involving APBB1.
- University of Washington
- Massachusetts General Hospital
- Hokkaido University
- Chinese University of Hong Kong
- Chungbuk National University
