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amyloid beta (A4) precursor protein-binding, family A, member 2
The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Multiple transcript v...
Normal tissues
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|---|---|---|---|
| Hemisphere of cerebe… |
100
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| Globus pallidus |
92
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| Vermis of cerebellum |
91
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| Substantia nigra |
90
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| Subthalamic nucleus |
88
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| Ventral tegmental ar… |
87
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Compounds
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|---|---|---|---|
| Levosalbutamol |
100
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| Meclofenamate |
91
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| Gliclazide |
83
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| Xamoterol |
80
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| 1zdp |
78
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| Noramidopyrine Metha… |
78
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 Individual Studies |
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Homo sapiens
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RNA Expression
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Comparative genome hybridization suggests a role for NRXN1 and APBA2 in schizophrenia.
Authors: George Kirov, Dilihan Gumus, Wei Chen, Nadine Norton, Lyudmila Georgieva, Murat Sari, Michael C O'Donovan, Fikret Erdogan, Michael J Owen, Hans-Hilger Ropers,…
Human molecular genetics 2008 Feb 1 -
Phosphorylation of the amino-terminal region of X11L regulates its interaction with APP.
Authors: Megumi Sakuma, Emi Tanaka, Hidenori Taru, Susumu Tomita, Sam Gandy, Angus C Nairn, Tadashi Nakaya, Tohru Yamamoto, Toshiharu Suzuki
Journal of neurochemistry 2009 Apr
Thought leaders and organizations working on research involving APBA2.
- University of Texas M.D. Anderson Cancer Center
- University of Tokyo
- Hokkaido University
- University of Utah Health Sciences Center
- Cardiff University
