NextBio

Help

arachidonate 5-lipoxygenase

This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also...

View Gene Details



Data Correlations | 1,183 studies

Help for Data Correlations View All
Tissues category icon Normal tissues
Score Help
Hemisphere of cerebe… 100 100
Pylorus 94 94
Femur 93 93
Synovial membrane 93 93
Vermis of cerebellum 93 93
Lymph node 93 93
View Top Normal tissues
Compounds category icon Compounds
Score Help
Diethylcarbamazine 100 100
Staph Enterotoxin B 84 84
Zinc Ion 83 83
Rituximab 73 73
Harman 71 71
Dimethylnitrosamine 70 70
View Top Compounds
Diseases category icon Diseases
Score Help
Asthma 100 100
Tenosynovial giant c… 100 100
Congenital cystic ad… 95 95
Coronary occlusion 94 94
Cytomegalovirus infe… 91 91
Smallpox 90 90
View Top Diseases

Individual Studies

  • Acute myeloid leukemia samples

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    Acute myeloid leukemia samples were karyotype and as well as the mutational status of different genes known to be associated with AML. The expression patterns were compared.

    Authors: Verhaak G Roel, Wouters J Bas, Erpelinck A Claudia et al.

    Organization: Broad Institute Cancer Meyerson 7 Cambri…

  • Drug target sets for approved compounds

    score: 100100 | Homo sapiens Homo sapiens | Therapeutic   Therapeutic

    The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.

    Authors: David S Wishart, Craig Knox, An Chi Guo et al.

    Organization: Department of Computing Science, Univers…
View All Individual Studies

Associated Researchers

Help for Associated Researchers

Thought leaders and organizations working on research involving ALOX5.

View All Author iconAuthors
  • Oliver Werz
  • Dieter Steinhilber
  • Olof Rådmark
  • Hooman Allayee
  • Andreas Koeberle
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • The Cleveland Clinic
  • University of Pittsburgh
  • GlaxoSmithKline
  • University of California, Davis
  • University of Florida
View All Affiliations icon Organizations
  • Eberhard Karls University Tuebingen
  • Karolinska Institutet
  • Karolinska University Hospital
  • University of Pennsylvania
  • University of Massachusetts Medical School

Clinical Trials | 15 trials

Help for Clinical Trials View All

Community

Help for Community
NextBio Users

  • No NextBio users were found for “ALOX5”.
    Complete your user profile with your interests, if you want others to find you within the NextBio community.

NextBio Groups

  • No NextBio groups were found for “ALOX5”.
    Be the first to start a group and share your interests with others within the NextBio community.

© 2010 NextBio