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angiotensinogen (serpin peptidase inhibitor, clade A, member 8)

The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development...

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Data Correlations | 1,068 studies

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Tissues category icon Normal tissues
Score Help
Locus ceruleus 100 100
Vestibular nuclear c… 85 85
Ventral tegmental ar… 85 85
Substantia nigra 84 84
Spinal cord 84 84
Fetal structure 83 83
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Compounds category icon Compounds
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Extract Of Bitter Or… 100 100
Flavanone 100 100
Glyburide 90 90
Chlorpyrifos 87 87
Garcinol 87 87
D-galactosamine 81 81
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Diseases category icon Diseases
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Dysplasia of kidney 100 100
Pre-eclampsia 99 99
Neuroendocrine carci… 68 68
Large cell carcinoma… 65 65
Hyperoxia 63 63
Adenocarcinoma of lu… 54 54
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Individual Studies

  • Inducible expression of PrPC in mouse skeletal muscles

    score: 100100 | Mus musculus Mus musculus | RNA Expression   RNA Expression

    Wild type (WT), PrP-null, and transgenic mice were fed food either lacking or containing 6g doxycycline (Dox)/kg food to induce PrPC expression. Skeletal muscles from the quadriceps of hind legs were removed at 0, 4, 7, 14, 30 and 60 days. Total RNA was isolated from these tissues for use in subseq…

    Authors: Liang Jingjing, Parchaliuk Debra, Medina Sarah et al.

    Organization: Public Health Agency of Canada Prion Dis…

  • OMIM - Congenital disorder

    score: 100100 | Homo sapiens Homo sapiens | Mutations/Phenotypic   Mutations/Phenotypic

    This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories.

    Source: NextBio Library/Mutation and Phenotypic data
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Associated Researchers

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Thought leaders and organizations working on research involving AGT.

View All Author iconAuthors
  • Friedrich C Luft
  • Ralf Dechend
  • Curt D Sigmund
  • Dominik N Muller
  • David G Harrison
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • National Heart, Lung, and Blood Institute (NHLBI)
  • University of Edinburgh
  • Medical University of Gdansk
  • Case Comprehensive Cancer Center
  • Holstebro Hospital
View All Affiliations icon Organizations
  • University of Iowa
  • University of Minnesota
  • Newcastle University
  • Scripps Research Institute
  • Royal College of Surgeons in Ireland

Clinical Trials | 244 trials

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Community

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