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aggrecan

This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene. [provided by RefSeq]

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Data Correlations | 899 studies

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Tissues category icon Normal tissues
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Segment of tracheobr… 100 100
Set of fingers 88 88
Spinal cord 85 85
Appendix 80 80
Femur 80 80
Salivary gland 80 80
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Compounds category icon Compounds
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Ciclolysal 100 100
Thymidine 92 92
Fipexide 86 86
Pantothenic Acid Cal… 81 81
Doxycycline Anhydrou… 78 78
Naaxia 74 74
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Diseases category icon Diseases
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Achondroplasia 100 100
Spondyloepiphyseal d… 99 99
Idiopathic thrombocy… 85 85
Dupuytren's disease … 84 84
Aggressive fibromato… 71 71
Pulmonary fibrosis 67 67
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Individual Studies

  • OMIM - Congenital disorder

    score: 100100 | Homo sapiens Homo sapiens | Mutations/Phenotypic   Mutations/Phenotypic

    This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories.

    Source: NextBio Library/Mutation and Phenotypic data

  • Mouse Phenotypes - Dwarfism

    score: 100100 | Mus musculus Mus musculus | Mutations/Phenotypic   Mutations/Phenotypic

    This study contains curated mouse gene mutation data extracted from the Mouse Genome Database (MGD) at The Jackson Laboratory, Bar Harbor, Maine. Additional computational processing and curation of mouse phenotype data was performed to further organize and group data from related phenotypes into uni…

    Source: NextBio Library/Mutation and Phenotypic data
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Associated Researchers

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Thought leaders and organizations working on research involving ACAN.

View All Author iconAuthors
  • N L Acan
  • E F Tezcan
  • Stefan Ehrlich
  • Ernst Pfeiffer
  • Ulrike Lehmkuhl
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Memorial Sloan-Kettering Cancer Center
View All Affiliations icon Organizations
  • Hacettepe University
  • Charité - Universitätsmedizin Berlin
  • Ankara University
  • University of Western Ontario
  • University of New South Wales

Clinical Trials | 1 trial

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