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c-abl oncogene 1, receptor tyrosine kinase

The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. Th...

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Data Correlations | 1,282 studies

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Tissues category icon Normal tissues
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Uterus 100 100
Salivary gland 97 97
Great saphenous vein 96 96
Myometrium 95 95
Thyroid gland 94 94
Fundus of stomach 94 94
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Compounds category icon Compounds
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Imatinib 100 100
Temsirolimus 93 93
Fazarabine 84 84
Methazolamide 78 78
Endotoxin 74 74
Echinomycin 73 73
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Diseases category icon Diseases
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Chronic myeloid leuk… 100 100
Adult T-cell leukemi… 99 99
Corneal burn 99 99
Idiopathic thrombocy… 89 89
Papilloma of skin 86 86
Toxicity due to radi… 83 83
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Individual Studies

  • Drug target sets for approved compounds

    score: 100100 | Homo sapiens Homo sapiens | Therapeutic   Therapeutic

    The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.

    Authors: David S Wishart, Craig Knox, An Chi Guo et al.

    Organization: Department of Computing Science, Univers…

  • CVB3-infected HeLa cells

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    HeLa cells profiled were serum starved and either preincubated with DMSO (vehicle), preincubated with U0126 (10µM in DMSO) and infected with CVB3 (MOI 10), or preincubated with DMSO (vehicle) and infected with CVB3.

    Authors: Yanagawa B, Luo H, Rezai N et al.

    Organization: iCAPTURE CENTRE Room 166, St. Paul's Hos…
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Associated Researchers

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Thought leaders and organizations working on research involving ABL1.

View All Author iconAuthors
  • Jorge Cortes
  • Peter Marynen
  • Giovanni Martinelli
  • Markus Warmuth
  • Alfonso Quintás-Cardama
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Fred Hutchinson Cancer Research Center
  • Gruppo Italiano Malattie EMatologiche dell'Adulto
  • Southwest Oncology Group
  • Cancer and Leukemia Group B
  • Masonic Cancer Center, University of Minnesota
View All Affiliations icon Organizations
  • University of Texas M. D. Anderson Cancer Center
  • University of Pennsylvania School of Medicine
  • Dana-Farber Cancer Institute
  • Imperial College London
  • St Jude Children's Research Hospital

Clinical Trials | 56 trials

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Community

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