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ATP-binding cassette, sub-family A (ABC1), member 1

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been ass...

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Data Correlations | 1,854 studies

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Tissues category icon Normal tissues
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Mesenteric lymph nod… 100 100
Epidermis 89 89
Globus pallidus 87 87
Pericardium 87 87
Adrenal cortex 85 85
Ganglion of cranial … 82 82
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Compounds category icon Compounds
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Lynestrenol 100 100
Etofenamate 98 98
Dimethisoquin 87 87
Epitiostanol 87 87
Nabumetone 84 84
Felodipine 84 84
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Diseases category icon Diseases
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Membranoproliferativ… 100 100
Familial hypoalphali… 100 100
Coronary artery dise… 99 99
Spinal cord injuries 66 66
Vaccine reaction 59 59
Cicatrization 58 58
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Individual Studies

  • Mouse Phenotypes - Familial lipoprotein deficiency

    score: 100100 | Mus musculus Mus musculus | Mutations/Phenotypic   Mutations/Phenotypic

    This study contains curated mouse gene mutation data extracted from the Mouse Genome Database (MGD) at The Jackson Laboratory, Bar Harbor, Maine. Additional computational processing and curation of mouse phenotype data was performed to further organize and group data from related phenotypes into uni…

    Source: NextBio Library/Mutation and Phenotypic data

  • Mouse Phenotypes - Kidney diseases

    score: 100100 | Mus musculus Mus musculus | Mutations/Phenotypic   Mutations/Phenotypic

    This study contains curated mouse gene mutation data extracted from the Mouse Genome Database (MGD) at The Jackson Laboratory, Bar Harbor, Maine. Additional computational processing and curation of mouse phenotype data was performed to further organize and group data from related phenotypes into uni…

    Source: NextBio Library/Mutation and Phenotypic data
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Associated Researchers

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Thought leaders and organizations working on research involving ABCA1.

View All Author iconAuthors
  • Michael R Hayden
  • John S Parks
  • Liam R Brunham
  • Roshni R Singaraja
  • Shinji Yokoyama
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • University Hospital, Basel, Switzerland
  • National Heart, Lung, and Blood Institute (NHLBI)
  • Schering-Plough
  • Bayside Health
  • University of Pennsylvania
View All Affiliations icon Organizations
  • University of British Columbia
  • Nagoya City University Graduate School of Medical Sciences
  • University of Washington
  • Kyoto University
  • University of Wisconsin - Madison

Clinical Trials | 18 trials

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Community

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