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[METHODS] Distinct DNA methylation patterns characterize differentiated human embryonic stem cells and developing human fetal liver
Genome Research. - May 31, 2009To investigate the role of DNA methylation during human development, we developed Methyl-seq, a method that assays DNA methylation at more than 90,000 regions throughout the genome. Performing Methyl-seq on human embryonic stem cells (hESCs), their derivatives, and human tissues allow…
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In Vitro Model to Study Chondrogenic Differentiation in Tendinopathy
American journal. - May 21, 2009BackgroundTreatment of midportion Achilles tendinopathy is hampered by limited knowledge of the pathophysiology.HypothesisChondrogenic differentiation of tendon cells might take place in midportion Achilles tendinopathy and could be used as a target for drug treatment. An in vitro mod…
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[LETTERS] Genomic mapping of binding regions for the Ecdysone receptor protein complex
Genome Research. - May 31, 2009We determined the physical locations of the heterodimeric Ecdysone receptor/Ultraspiracle (ECR/USP) nuclear hormone receptor complex throughout the entire nonrepetitive genome of Drosophila melanogaster using a cell line (Kc167) that differentiates in response to 20-hydroxyecdysone (2…
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Erythroid GATA1 function revealed by genome-wide analysis of transcription factor occupancy, histone modifications, and mRNA expression [ARTICLES]
Genome Research. - November 03, 2009The transcription factor GATA1 regulates an extensive program of gene activation and repression during erythroid development. However, the associated mechanisms, including the contributions of distal versus proximal cis-regulatory modules, co-occupancy with other transcription factors…
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[Review] Clinician's guide to human papillomavirus immunology: knowns and unknowns
Lancet. - May 22, 2009Oncogenic human papillomavirus (HPV) is a common genital infection that has the potential to develop into cervical cancer in some women. This Review summarises current knowledge on the mechanisms of host immunity that help prevent and control HPV infection and the viral factors that e…
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[RESEARCH] Genomic mapping of binding regions for the ecdysone receptor protein complex
Genome Research. - February 22, 2009We determined the physical locations of the heterodimeric EcR/USP nuclear hormone receptor complex throughout the entire non-repetitive genome of Drosophila melanogaster using a cell line (Kc167) that differentiates in response to 20-hydroxyecdysone (20-HE). 20-HE, the natural ligand …
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[METHODS] DNA methylation profile of tissue-dependent and differentially methylated regions (T-DMRs) in mouse promoter regions demonstrating tissue-specific gene expression
Genome Research. - November 30, 2008DNA methylation constitutes an important epigenetic regulation mechanism in many eukaryotes, although the extent of DNA methylation in the regulation of gene expression in the mammalian genome is poorly understood. We developed D-REAM, a genome-wide DNA methylation analysis method for…
