1 to 10 of 50 literature results

• Rare chromosomal deletions and duplications increase risk of schizophrenia.

  Schizophrenia is a severe mental disorder marked by hallucinations, delusions, cognitive deficits and apathy, with a heritability estimated at 73-90% (ref. 1). Inheritance patterns are complex, and th…

  Authors: International Schizophrenia Consortium

  Source: Nature 2008 Sep 11

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• Common polygenic variation contributes to risk of schizophrenia and bipolar disorder.

  Schizophrenia is a severe mental disorder with a lifetime risk of about 1%, characterized by hallucinations, delusions and cognitive deficits, with heritability estimated at up to 80%. We performed a …

  Authors: International Schizophrenia Consortium, Shaun M Purcell, Naomi R Wray, Jennifer L Stone, Peter M Visscher, Michael C O'Donovan, Patrick F Sullivan, Pamela Sklar

  Source: Nature 2009 Aug 6

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• Schizophrenia.

  Schizophrenia is still one of the most mysterious and costliest mental disorders in terms of human suffering and societal expenditure. Here, we focus on the key developments in biology, epidemiology, …

  Authors: Jim van Os, Shitij Kapur

  Source: Lancet 2009 Aug 22

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• Large recurrent microdeletions associated with schizophrenia.

  Reduced fecundity, associated with severe mental disorders, places negative selection pressure on risk alleles and may explain, in part, why common variants have not been found that confer risk of dis…

  Authors: Hreinn Stefansson, Dan Rujescu, Sven Cichon, Olli P H Pietiläinen, Andres Ingason, Stacy Steinberg, Ragnheidur Fossdal, Engilbert Sigurdsson, Thordur Sigmundsson, Jacobine E Buizer-Voskamp,…

  Source: Nature 2008 Sep 11

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• Microduplications of 16p11.2 are associated with schizophrenia.

  Recurrent microdeletions and microduplications of a 600-kb genomic region of chromosome 16p11.2 have been implicated in childhood-onset developmental disorders. We report the association of 16p11.2 mi…

  Authors: Shane E McCarthy, Vladimir Makarov, George Kirov, Anjene M Addington, Jon McClellan, Seungtai Yoon, Diana O Perkins, Diane E Dickel, Mary Kusenda, Olga Krastoshevsky,…

  Source: Nature genetics 2009 Nov

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• Identification of loci associated with schizophrenia by genome-wide association and follow-up.

  We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10(-5) in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong in…

  Authors: Michael C O'Donovan, Nicholas Craddock, Nadine Norton, Hywel Williams, Timothy Peirce, Valentina Moskvina, Ivan Nikolov, Marian Hamshere, Liam Carroll, Lyudmila Georgieva,…

  Source: Nature genetics 2008 Sep

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• Common variants conferring risk of schizophrenia.

  Schizophrenia is a complex disorder, caused by both genetic and environmental factors and their interactions. Research on pathogenesis has traditionally focused on neurotransmitter systems in the brai…

  Authors: Hreinn Stefansson, Roel A Ophoff, Stacy Steinberg, Ole A Andreassen, Sven Cichon, Dan Rujescu, Thomas Werge, Olli P H Pietiläinen, Ole Mors, Preben B Mortensen,…

  Source: Nature 2009 Aug 6

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• Common variants on chromosome 6p22.1 are associated with schizophrenia.

  Schizophrenia, a devastating psychiatric disorder, has a prevalence of 0.5-1%, with high heritability (80-85%) and complex transmission. Recent studies implicate rare, large, high-penetrance copy numb…

  Authors: Jianxin Shi, Douglas F Levinson, Jubao Duan, Alan R Sanders, Yonglan Zheng, Itsik Pe'er, Frank Dudbridge, Peter A Holmans, Alice S Whittemore, Bryan J Mowry,…

  Source: Nature 2009 Aug 6

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• A primate-specific, brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophrenia.

  Organized neuronal firing is crucial for cortical processing and is disrupted in schizophrenia. Using rapid amplification of 5' complementary DNA ends in human brain, we identified a primate-specific …

  Authors: Stephen J Huffaker, Jingshan Chen, Kristin K Nicodemus, Fabio Sambataro, Feng Yang, Venkata Mattay, Barbara K Lipska, Thomas M Hyde, Jian Song, Dan Rujescu,…

  Source: Nature medicine 2009 May

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• Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study.

  BACKGROUND: Whether schizophrenia and bipolar disorder are the clinical outcomes of discrete or shared causative processes is much debated in psychiatry. We aimed to assess genetic and environmental c…

  Authors: Paul Lichtenstein, Benjamin H Yip, Camilla Björk, Yudi Pawitan, Tyrone D Cannon, Patrick F Sullivan, Christina M Hultman

  Source: Lancet 2009 Jan 17

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