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BACKGROUND AND AIMS:: The protective component of the host response to dextran sodium sulfate colitis in the mouse is mediated through the activation of TLR4, the induction of COX-2 and PGE2 productio…
Authors: Ling Zheng, Terrence Riehl, William F Stenson
Source: Gastroenterology 2009 Sep 1
View Full TextThrombin is a key factor in the stimulation of fibrin deposition, angiogenesis, proinflammatory processes, and proliferation of fibroblast-like cells. Abnormalities in these processes are primary feat…
Authors: Xiaotian Chang, Ryo Yamada, Kazuhiko Yamamoto
Source: Arthritis research & therapy 2005
View Full TextABSTRACT : Magnetic resonance imaging remains the only non-invasive method to assess the quality of cartilage repair procedures, but ideally would be complemented by other modalities, particularly blo…
Authors: Andreas H Gomoll
Source: Arthritis research & therapy 2009
View Full TextINTRODUCTION: The purpose of this study was to evaluate serum chondroitin sulfate (CS) and hyaluronic acid (HA) levels and the capability of cartilage repair of full-thickness cartilage defects after …
Authors: Korakot Nganvongpanit, Peraphan Pothacharoen, Patama Chaochird, Kasisin Klunklin, Kanawee Warrit, Jongkolnee Settakorn, Nuttaya Pattamapaspong, Sirichai Luevitoonvechkij, Olarn Arpornchayanon, Prachya Kongtawelert,…
Source: Arthritis research & therapy 2009
View Full TextBACKGROUND: Surfactant dysfunction due to inhibition is involved in the pathophysiology of meconium aspiration syndrome. Dextran addition has been shown to reverse exogenous surfactant inactivation by…
Authors: Matthias Ochs, Markus Schüttler, Guido Stichtenoth, Egbert Herting
Source: Respiratory research 2006
View Full TextPolysaccharides are being processed into biomaterials for numerous biological applications due to their native source in numerous tissues and biological functions. For instance, hyaluronic acid (HA) i…
Authors: Sujata Sahoo, Cindy Chung, Sudhir Khetan, Jason A Burdick
Source: Biomacromolecules 2008 Apr
View Free Full TextOBJECTIVE: To evaluate the efficacy and tolerability of a single intraarticular (IA) injection of hyaluronic acid (HA) for the treatment of hip osteoarthritis (OA). METHODS: A multicenter, randomized,…
Authors: Pascal Richette, Philippe Ravaud, Thierry Conrozier, Liana Euller-Ziegler, Bernard Mazières, Yves Maugars, Denis Mulleman, Pierre Clerson, Xavier Chevalier
Source: Arthritis and rheumatism 2009 Mar
View Full TextHyaluronic acid (HA) promotes tumor metastasis and is an accurate diagnostic marker for bladder cancer. HA is synthesized by HA synthases HAS1, HAS2, or HAS3. We have previously shown that HAS1 expres…
Authors: Roozbeh Golshani, Luis Lopez, Veronica Estrella, Mario Kramer, Naoko Iida, Vinata B Lokeshwar
Source: Cancer research 2008 Jan 15
View Full TextHyaluronic acid is a polysaccharide with viscoelastic and mechanical properties that are crucial for the normal functioning of osteoarticular junctions. It is demonstrated that introduction of a hexad…
Authors: Ivana Finelli, Ester Chiessi, Devis Galesso, Davide Renier, Gaio Paradossi
Source: Macromolecular bioscience 2009 Jul 7
View Full TextPURPOSE: Gene therapy offers a promising alternative for the treatment of ocular diseases. However, the implementation of this type of therapy is actually hampered by the lack of an efficient ocular g…
Authors: Maria de la Fuente, Begoña Seijo, Maria J Alonso
Source: Investigative ophthalmology & visual science 2008 May
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