1 to 10 of 524,192 literature results

• Positively selecting peptides: their job does not end in the thymus.

  Peptides able to positively select major histocompatibility complex class II-restricted thymocytes have not yet been defined. Two new reports identify and ascribe important extrathymic functions ...

  Authors: Kai W Wucherpfennig, Etienne Gagnon

  Source: Nature immunology 2009 Nov

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• Design of protein-interaction specificity gives selective bZIP-binding peptides.

  Interaction specificity is a required feature of biological networks and a necessary characteristic of protein or small-molecule reagents and therapeutics. The ability to alter or inhibit protein inte ...

  Authors: Gevorg Grigoryan, Aaron W Reinke, Amy E Keating

  Source: Nature 2009 Apr 16

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• Unique autoreactive T cells recognize insulin peptides generated within the islets of Langerhans in autoimmune diabetes.

  In addition to the genetic framework, there are two other critical requirements for the development of tissue-specific autoimmune disease. First, autoreactive T cells need to escape thymic negative se ...

  Authors: James F Mohan, Matteo G Levisetti, Boris Calderon, Jeremy W Herzog, Shirley J Petzold, Emil R Unanue

  Source: Nature immunology 2010 Apr

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• Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure.

  We examined the association of common variants at the NPPA-NPPB locus with circulating concentrations of the natriuretic peptides, which have blood pressure-lowering properties. We genotyped SNPs ...

  Authors: Christopher Newton-Cheh, Martin G Larson, Ramachandran S Vasan, Daniel Levy, Kenneth D Bloch, Aarti Surti, Candace Guiducci, Sekar Kathiresan, Emelia J Benjamin, Joachim Struck,…

  Source: Nature genetics 2009 Mar

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• Peptide bond formation destabilizes Shine-Dalgarno interaction on the ribosome.

  The ribosome is a molecular machine that translates the genetic code contained in the messenger RNA into an amino acid sequence through repetitive cycles of transfer RNA selection, peptide bond ...

  Authors: Sotaro Uemura, Magdalena Dorywalska, Tae-Hee Lee, Harold D Kim, Joseph D Puglisi, Steven Chu

  Source: Nature 2007 Mar 22

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• Signal peptides are allosteric activators of the protein translocase.

  Extra-cytoplasmic polypeptides are usually synthesized as 'preproteins' carrying amino-terminal, cleavable signal peptides and secreted across membranes by translocases. The main bacterial ...

  Authors: Giorgos Gouridis, Spyridoula Karamanou, Ioannis Gelis, Charalampos G Kalodimos, Anastassios Economou

  Source: Nature 2009 Nov 19

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• Phosphorylation-dependent interaction between antigenic peptides and MHC class I: a molecular basis for the presentation of transformed self.

  Protein phosphorylation generates a source of phosphopeptides that are presented by major histocompatibility complex class I molecules and recognized by T cells. As deregulated phosphorylation is a ha ...

  Authors: Fiyaz Mohammed, Mark Cobbold, Angela L Zarling, Mahboob Salim, Gregory A Barrett-Wilt, Jeffrey Shabanowitz, Donald F Hunt, Victor H Engelhard, Benjamin E Willcox

  Source: Nature immunology 2008 Nov

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• A recombinant polypeptide extends the in vivo half-life of peptides and proteins in a tunable manner.

  , called XTEN, to a peptide or protein provides an apparently g… ...

  Authors: Volker Schellenberger, Chia-Wei Wang, Nathan C Geething, Benjamin J Spink, Andrew Campbell, Wayne To, Michael D Scholle, Yong Yin, Yi Yao, Oren Bogin,…

  Source: Nature biotechnology 2009 Dec

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• Peptides as materials.

  This review focuses on the creation of electronically active peptide-based biomaterials and how such materials may be deposited onto surfaces to create integrated bionanocircuits. We describe recent ...

  Authors: Brian J Pepe-Mooney, Robert Fairman

  Source: Current opinion in structural biology 2009 Aug

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• Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA.

  Methicillin-resistant Staphylococcus aureus (MRSA) remains a major human pathogen. Traditionally, MRSA infections occurred exclusively in hospitals and were limited to immunocompromised patients or in ...

  Authors: Rong Wang, Kevin R Braughton, Dorothee Kretschmer, Thanh-Huy L Bach, Shu Y Queck, Min Li, Adam D Kennedy, David W Dorward, Seymour J Klebanoff, Andreas Peschel,…

  Source: Nature medicine 2007 Dec

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