1 to 10 of 70,786 literature results

• Antimicrobial treatment for early, limited Mycobacterium ulcerans infection: a randomised controlled trial.

  BACKGROUND: Surgical debridement was the standard treatment for Mycobacterium ulcerans infection (Buruli ulcer disease) until WHO issued provisional guidelines in 2004 recommending treatment ...

  Authors: Willemien A Nienhuis, Ymkje Stienstra, William A Thompson, Peter C Awuah, K Mohammed Abass, Wilson Tuah, Nana Yaa Awua-Boateng, Edwin O Ampadu, Vera Siegmund, Jan P Schouten,…

  Source: Lancet 2010 Feb 20

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• A replication clock for Mycobacterium tuberculosis.

  Few tools exist to assess replication of chronic pathogens during infection. This has been a considerable barrier to understanding latent tuberculosis, and efforts to develop new therapies generally a ...

  Authors: Wendy P Gill, Nada S Harik, Molly R Whiddon, Reiling P Liao, John E Mittler, David R Sherman

  Source: Nature medicine 2009 Feb

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• Comparative genomic and phylogeographic analysis of Mycobacterium leprae.

  Reductive evolution and massive pseudogene formation have shaped the 3.31-Mb genome of Mycobacterium leprae, an unculturable obligate pathogen that causes leprosy in humans. The complete genome ...

  Authors: Marc Monot, Nadine Honoré, Thierry Garnier, Nora Zidane, Diana Sherafi, Alberto Paniz-Mondolfi, Masanori Matsuoka, G Michael Taylor, Helen D Donoghue, Abi Bouwman,…

  Source: Nature genetics 2009 Dec

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• Interferon-gamma-responsive nonhematopoietic cells regulate the immune response to Mycobacterium tuberculosis.

  Immunity to Mycobacterium tuberculosis in humans and in mice requires interferon gamma (IFN-gamma). Whereas IFN-gamma has been studied extensively for its effects on macrophages in tuberculosis, we ...

  Authors: Ludovic Desvignes, Joel D Ernst

  Source: Immunity 2009 Dec 18

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• Contrasting persistence strategies in Salmonella and Mycobacterium.

  Long-term survival of persistent bacterial pathogens in mammalian hosts critically depends on their ability to avoid elimination by innate and adaptive immune responses. The persistent human pathogens ...

  Authors: Anna D Tischler, John D McKinney

  Source: Current opinion in microbiology 2010 Feb

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• Mycobacterium tuberculosis evades macrophage defenses by inhibiting plasma membrane repair.

  Induction of macrophage necrosis is a strategy used by virulent Mycobacterium tuberculosis (Mtb) to avoid innate host defense. In contrast, attenuated Mtb causes apoptosis, which limits bacterial ...

  Authors: Maziar Divangahi, Minjian Chen, Huixian Gan, Danielle Desjardins, Tyler T Hickman, David M Lee, Sarah Fortune, Samuel M Behar, Heinz G Remold

  Source: Nature immunology 2009 Aug

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• Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis.

  Mycobacterium marinum, a ubiquitous pathogen of fish and amphibia, is a near relative of Mycobacterium tuberculosis, the etiologic agent of tuberculosis in humans. The genome of the M strain of M ...

  Authors: Timothy P Stinear, Torsten Seemann, Paul F Harrison, Grant A Jenkin, John K Davies, Paul D R Johnson, Zahra Abdellah, Claire Arrowsmith, Tracey Chillingworth, Carol Churcher,…

  Source: Genome research 2008 May

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• Cyclic AMP intoxication of macrophages by a Mycobacterium tuberculosis adenylate cyclase.

  With 8.9 million new cases and 1.7 million deaths per year, tuberculosis is a leading global killer that has not been effectively controlled. The causative agent, Mycobacterium tuberculosis ...

  Authors: Nisheeth Agarwal, Gyanu Lamichhane, Radhika Gupta, Scott Nolan, William R Bishai

  Source: Nature 2009 Jul 2

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• CarD is an essential regulator of rRNA transcription required for Mycobacterium tuberculosis persistence.

  Mycobacterium tuberculosis is arguably the world's most successful infectious agent because of its ability to control its own cell growth within the host. Bacterial growth rate is closely coupled ...

  Authors: Christina L Stallings, Nicolas C Stephanou, Linda Chu, Ann Hochschild, Bryce E Nickels, Michael S Glickman

  Source: Cell 2009 Jul 10

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• A membrane protein preserves intrabacterial pH in intraphagosomal Mycobacterium tuberculosis.

  Acidification of the phagosome is considered to be a major mechanism used by macrophages against bacteria, including Mycobacterium tuberculosis (Mtb). Mtb blocks phagosome acidification ...

  Authors: Omar H Vandal, Lynda M Pierini, Dirk Schnappinger, Carl F Nathan, Sabine Ehrt

  Source: Nature medicine 2008 Aug

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