1 to 10 of 1,142,492 literature results

• Forward genetic dissection of immunity to infection in the mouse.

  Forward genetics is an experimental approach in which gene mapping and positional cloning are used to elucidate the molecular mechanisms underlying phenotypic differences between two individuals for a ...

  Authors: S M Vidal, D Malo, J-F Marquis, P Gros

  Source: Annual review of immunology 2008

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• Reverse engineering the mouse brain.

  Behaviour is governed by activity in highly structured neural circuits. Genetically targeted sensors and switches facilitate measurement and manipulation of activity in vivo, linking activity in defin ...

  Authors: Daniel H O'Connor, Daniel Huber, Karel Svoboda

  Source: Nature 2009 Oct 15

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• In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium.

  Haematopoietic stem cells (HSCs), responsible for blood production in the adult mouse, are first detected in the dorsal aorta starting at embryonic day 10.5 (E10.5). Immunohistological analysis ...

  Authors: Jean-Charles Boisset, Wiggert van Cappellen, Charlotte Andrieu-Soler, Niels Galjart, Elaine Dzierzak, Catherine Robin

  Source: Nature 2010 Mar 4

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• A mouse for all reasons.

  Three major mouse knockout programs are underway worldwide, working together to mutate all protein-encoding genes in the mouse using a combination of gene trapping and gene targeting in mouse ...

  Authors: International Mouse Knockout Consortium, Francis S Collins, Janet Rossant, Wolfgang Wurst

  Source: Cell 2007 Jan 12

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• Evidence of Xist RNA-independent initiation of mouse imprinted X-chromosome inactivation.

  XX female mammals undergo transcriptional silencing of most genes on one of their two X chromosomes to equalize X-linked gene dosage with XY males in a process referred to as X-chromosome inactivation ...

  Authors: Sundeep Kalantry, Sonya Purushothaman, Randall Bryant Bowen, Joshua Starmer, Terry Magnuson

  Source: Nature 2009 Jul 30

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• Development of a novel mouse glioma model using lentiviral vectors.

  We report the development of a new method to induce glioblastoma multiforme in adult immunocompetent mice by injecting Cre-loxP-controlled lentiviral vectors expressing oncogenes. Cell type- or region ...

  Authors: Tomotoshi Marumoto, Ayumu Tashiro, Dinorah Friedmann-Morvinski, Miriam Scadeng, Yasushi Soda, Fred H Gage, Inder M Verma

  Source: Nature medicine 2009 Jan

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• Specifying mouse embryonic germ cells.

  Male germ cells are induced to form from the epiblast of the mouse embryo by a combination of WNT and bone morphogenetic protein signals. Ohinata et al. (2009) now clarify the steps of mouse germ ...

  Authors: Patrick P L Tam, David A F Loebel

  Source: Cell 2009 May 1

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• Genetic architecture of mouse skin inflammation and tumour susceptibility.

  Germline polymorphisms in model organisms and humans influence susceptibility to complex trait diseases such as inflammation and cancer. Mice of the Mus spretus species are resistant to tumour develop ...

  Authors: David A Quigley, Minh D To, Jesús Pérez-Losada, Facundo G Pelorosso, Jian-Hua Mao, Hiroki Nagase, David G Ginzinger, Allan Balmain

  Source: Nature 2009 Mar 26

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• Applying mouse complex-trait resources to behavioural genetics.

  Studies of the genetic basis of behaviour in mice are at a turning point. Soon, new resources will enable the behavioural function of all genes to be tested and the networks of genes, messenger RNAs a ...

  Authors: Jonathan Flint, Richard Mott

  Source: Nature 2008 Dec 11

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• Renaissance for mouse models of human hematopoiesis and immunobiology.

  More than 20 years after the first successful engraftment of human leukocytes and hematopoietic organs in mice, scientists met for the 2nd International Workshop on Humanized Mice to discuss progress ...

  Authors: Markus G Manz, James P Di Santo

  Source: Nature immunology 2009 Oct

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