1 to 10 of 91,073 literature results

• Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis.

  Aggrecan cleavage by a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 5 (ADAMTS-5) is crucial for the breakdown of cartilage matrix during osteoarthritis, a degenerative ...

  Authors: Frank Echtermeyer, Jessica Bertrand, Rita Dreier, Ingmar Meinecke, Katja Neugebauer, Martin Fuerst, Yun Jong Lee, Yeong Wook Song, Christine Herzog, Gregor Theilmeier,…

  Source: Nature medicine 2009 Sep

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• Nucleotide-sugar transporter SLC35D1 is critical to chondroitin sulfate synthesis in cartilage and skeletal development in mouse and human.

  Proteoglycans are a family of extracellular macromolecules comprised of glycosaminoglycan chains of a repeated disaccharide linked to a central core protein. Proteoglycans have critical roles in chond ...

  Authors: Shuichi Hiraoka, Tatsuya Furuichi, Gen Nishimura, Shunichi Shibata, Masaki Yanagishita, David L Rimoin, Andrea Superti-Furga, Peter G Nikkels, Minako Ogawa, Kayoko Katsuyama,…

  Source: Nature medicine 2007 Nov

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• ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro.

  Aggrecan is the major proteoglycan in cartilage, endowing this tissue with the unique capacity to bear load and resist compression. In arthritic cartilage, aggrecan is degraded by one or more ...

  Authors: Heather Stanton, Fraser M Rogerson, Charlotte J East, Suzanne B Golub, Kate E Lawlor, Clare T Meeker, Christopher B Little, Karena Last, Pamela J Farmer, Ian K Campbell,…

  Source: Nature 2005 Mar 31

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• Modulating hedgehog signaling can attenuate the severity of osteoarthritis.

  Osteoarthritis is associated with the irreversible degeneration of articular cartilage. Notably, in this condition, articular cartilage chondrocytes undergo phenotypic and gene expression changes ...

  Authors: Alvin C Lin, Brian L Seeto, Justyna M Bartoszko, Michael A Khoury, Heather Whetstone, Louisa Ho, Claire Hsu, S Amanda Ali, Amanda S Ali, Benjamin A Alman

  Source: Nature medicine 2009 Dec

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• Synovial fibroblasts spread rheumatoid arthritis to unaffected joints.

  Active rheumatoid arthritis originates from few joints but subsequently affects the majority of joints. Thus far, the pathways of the progression of the disease are largely unknown. As rheumatoid arth ...

  Authors: Stephanie Lefèvre, Anette Knedla, Christoph Tennie, Andreas Kampmann, Christina Wunrau, Robert Dinser, Adelheid Korb, Eva-Maria Schnäker, Ingo H Tarner, Paul D Robbins,…

  Source: Nature medicine 2009 Dec

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• Biofunctional polymer nanoparticles for intra-articular targeting and retention in cartilage.

  The extracellular matrix of dense, avascular tissues presents a barrier to entry for polymer-based therapeutics, such as drugs encapsulated within polymeric particles. Here, we present an approach by ...

  Authors: Dominique A Rothenfluh, Harry Bermudez, Conlin P O'Neil, Jeffrey A Hubbell

  Source: Nature materials 2008 Mar

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• Gli2 and p53 cooperate to regulate IGFBP-3- mediated chondrocyte apoptosis in the progression from benign to malignant cartilage tumors.

  Clinical evidence suggests that benign cartilage lesions can progress to malignant chondrosarcoma, but the molecular events in this progression are unknown. Mice that develop benign cartilage lesions ...

  Authors: Louisa Ho, Aneta Stojanovski, Heather Whetstone, Qing Xia Wei, Elaine Mau, Jay S Wunder, Benjamin Alman

  Source: Cancer cell 2009 Aug 4

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• Engineering cartilage tissue.

  Cartilage tissue engineering is emerging as a technique for the regeneration of cartilage tissue damaged due to disease or trauma. Since cartilage lacks regenerative capabilities, it is essential ...

  Authors: Cindy Chung, Jason A Burdick

  Source: Advanced drug delivery reviews 2008 Jan 14

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• Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis.

  Human osteoarthritis is a progressive disease of the joints characterized by degradation of articular cartilage. Although disease initiation may be multifactorial, the cartilage destruction appears ...

  Authors: Sonya S Glasson, Roger Askew, Barbara Sheppard, Brenda Carito, Tracey Blanchet, Hak-Ling Ma, Carl R Flannery, Diane Peluso, Kim Kanki, Zhiyong Yang,…

  Source: Nature 2005 Mar 31

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• Palaeobiology: calcification of early vertebrate cartilage.

  of their endoskeleton are composed of huge, clumped chondrocytes (cartilag… ...

  Authors: Philippe Janvier, Marius Arsenault

  Source: Nature 2002 Jun 6

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