1 to 10 of 1,920 literature results

• Efficacy and safety of tarenflurbil in mild to moderate Alzheimer's disease: a randomised phase II trial.

  BACKGROUND: The amyloid-beta peptide Abeta(42) has been implicated in the pathogenesis of Alzheimer's disease (AD). We aimed to test the effects of tarenflurbil, a selective Abeta(42)-lowering agent (…

  Authors: Gordon K Wilcock, Sandra E Black, Suzanne B Hendrix, Kenton H Zavitz, Edward A Swabb, Mark A Laughlin, Tarenflurbil Phase II Study investigators

  Source: Lancet neurology 2008 Jun

  View Full Text

• The aryl propionic acid R-flurbiprofen selectively induces p75NTR-dependent decreased survival of prostate tumor cells.

  Epidemiologic studies show that patients chronically consuming nonsteroidal anti-inflammatory drugs (NSAID) for arthritis exhibit a reduced incidence of prostate cancer. In addition, some NSAIDs show …

  Authors: Emily J Quann, Fatima Khwaja, Kenton H Zavitz, Daniel Djakiew

  Source: Cancer research 2007 Apr 1

  View Full Text

• Selective modulation of amyloid-beta peptide degradation by flurbiprofen, fenofibrate, and related compounds regulates Abeta levels.

  Gamma-secretase modulators (GSMs) include selected non-steroidal anti-inflammatory drugs such as flurbiprofen that selectively lowers the neurotoxic amyloid-beta peptide Abeta(1-42). GSMs are attracti…

  Authors: Samer O Abdul-Hay, Praneeth Edirisinghe, Gregory R J Thatcher

  Source: Journal of neurochemistry 2009 Nov

  View Full Text

• Pretreatment with flurbiprofen axetil, flurbiprofen axetil preceded by venous occlusion, and a mixture of flurbiprofen axetil and propofol in reducing pain on injection of propofol in adult Japanese surgical patients: a prospective, randomized, double-blind, placebo-controlled study.

  BACKGROUND: Pain on injection of propofol is a common clinical problem. Flurbiprofen axetil, an injectable prodrug of flurbiprofen, with or without venous occlusion has been reported to reduce this pa…

  Authors: Yoshitaka Fujii, Michiyo Itakura

  Source: Clinical therapeutics 2009 Apr

  View Full Text

• Tarenflurbil: a shot on goal.

  Authors: Paul S Aisen

  Source: Lancet neurology 2008 Jun

  View Full Text

• NO-flurbiprofen reduces amyloid-beta, is neuroprotective in cell culture, and enhances cognition in response to cholinergic blockade.

  The non-steroidal anti-inflammatory drug flurbiprofen is a selective amyloid lowering agent which has been studied clinically in Alzheimer's disease. HCT-1026 is an ester prodrug of flurbiprofen incor…

  Authors: Samer O Abdul-Hay, Jia Luo, Rezene T Ashghodom, Gregory R J Thatcher

  Source: Journal of neurochemistry 2009 Nov

  View Full Text

• The individual and combined effects of U50,488, and flurbiprofen axetil on visceral pain in conscious rats.

  We examined the effects of U50,488, a kappa-opioid receptor agonist, and flurbiprofen axetil, a nonsteroidal antiinflammatory drug, in a visceral pain model using conscious rats. U50,488 produced visc…

  Authors: Takayuki Kitamura, Makoto Ogawa, Yoshitsugu Yamada

  Source: Anesthesia and analgesia 2009 Jun

  View Full Text

• Why Did Tarenflurbil Fail in Alzheimer's Disease?

  There has been a lot of disappointment surrounding the recent failure of the largest ever study in patients with Alzheimer's disease (AD) with tarenflurbil, a compound believed to modulate the activit…

  Authors: Bruno P Imbimbo

  Source: Journal of Alzheimer's disease : JAD 2009 Jun 19

  View Full Text

• Nitroflurbiprofen, a nitric oxide-releasing cyclooxygenase inhibitor, improves cirrhotic portal hypertension in rats.

  BACKGROUND & AIMS: We studied whether administration of nitroflurbiprofen (HCT-1026), a cyclooxygenase inhibitor with nitric oxide (NO)-donating properties, modulates the increased intrahepatic vascul…

  Authors: Wim Laleman, Lien Van Landeghem, Ingrid Van der Elst, Marcel Zeegers, Johan Fevery, Frederik Nevens

  Source: Gastroenterology 2007 Feb

  View Full Text

• Determination of flurbiprofen enantiomers in plasma using a single-isomer amino cyclodextrin derivative in nonaqueous capillary electrophoresis.

  A nonaqueous capillary electrophoresis (NACE) assay was developed for the separation and determination of flurbiprofen enantiomers in plasma samples using 6-monodeoxy-6-mono(3-hydroxy)propylamino-beta…

  Authors: Anne Rousseau, Matteo Pedrini, Patrice Chiap, Robert Ivanyi, Jacques Crommen, Marianne Fillet, Anne-Catherine Servais

  Source: Electrophoresis 2008 Sep

  View Full Text