1 to 10 of 86,966 literature results

• TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation.

  Dendritic cells (DCs) are professional antigen-presenting cells that have the ability to sense infection and tissue stress, sample and present antigen to T lymphocytes, and induce different forms of i…

  Authors: Yong-Jun Liu, Vasilli Soumelis, Norihiko Watanabe, Tomoki Ito, Yui-Hsi Wang, Rene de Waal Malefyt, Miyuki Omori, Baohua Zhou, Steven F Ziegler

  Source: Annual review of immunology 2007

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• Foxp3+ regulatory T cells: differentiation, specification, subphenotypes.

  Regulatory T cells (T(reg) cells) characterized by expression of the transcription factor Foxp3 play a key role in immune homeostasis. Rather than a monomorphic population strictly determined by Foxp3…

  Authors: Markus Feuerer, Jonathan A Hill, Diane Mathis, Christophe Benoist

  Source: Nature immunology 2009 Jul

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• Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells.

  Self-renewing cell populations such as hematopoietic stem cells and memory B and T lymphocytes might be regulated by shared signaling pathways. The Wnt-beta-catenin pathway is an evolutionarily conser…

  Authors: Luca Gattinoni, Xiao-Song Zhong, Douglas C Palmer, Yun Ji, Christian S Hinrichs, Zhiya Yu, Claudia Wrzesinski, Andrea Boni, Lydie Cassard, Lindsay M Garvin,…

  Source: Nature medicine 2009 Jul

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• mTOR regulates memory CD8 T-cell differentiation.

  Memory CD8 T cells are a critical component of protective immunity, and inducing effective memory T-cell responses is a major goal of vaccines against chronic infections and tumours. Considerable effo…

  Authors: Koichi Araki, Alexandra P Turner, Virginia Oliva Shaffer, Shivaprakash Gangappa, Susanne A Keller, Martin F Bachmann, Christian P Larsen, Rafi Ahmed

  Source: Nature 2009 Jul 2

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• Foxp3-dependent programme of regulatory T-cell differentiation.

  Regulatory CD4+ T cells (Tr cells), the development of which is critically dependent on X-linked transcription factor Foxp3 (forkhead box P3), prevent self-destructive immune responses. Despite its im…

  Authors: Marc A Gavin, Jeffrey P Rasmussen, Jason D Fontenot, Valeria Vasta, Vincent C Manganiello, Joseph A Beavo, Alexander Y Rudensky

  Source: Nature 2007 Feb 15

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• Suppressors of cytokine signaling (SOCS) in T cell differentiation, maturation, and function.

  Cytokines are key modulators of T cell biology, but their influence can be attenuated by suppressors of cytokine signaling (SOCS), a family of proteins consisting of eight members, SOCS1-7 and CIS. SO…

  Authors: Douglas C Palmer, Nicholas P Restifo

  Source: Trends in immunology 2009 Oct 29

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• Diversity in CD8(+) T cell differentiation.

  CD8(+) T cells are key effector cells of the adaptive immune system, however their activity must be tightly regulated to allow pathogen clearance whilst preventing immunopathology and autoimmunity. In…

  Authors: Ian A Parish, Susan M Kaech

  Source: Current opinion in immunology 2009 Jun

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• The unconventional role of LT alpha beta in T cell differentiation.

  Lymphotoxin (LT)alphabeta, a member of the tumor necrosis factor cytokine superfamily, and its receptor, the LTbeta receptor (LTbetaR), have a well defined role in secondary lymphoid organogenesis but…

  Authors: Dirk Elewaut, Carl F Ware

  Source: Trends in immunology 2007 Apr

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• Thymic microenvironments for T cell differentiation and selection.

  The adult thymus provides a variety of specialized microenvironments that support and direct T cell differentiation and selection. In this review, we summarize recent advances in the understanding of …

  Authors: Ena Ladi, Xinye Yin, Tatyana Chtanova, Ellen A Robey

  Source: Nature immunology 2006 Apr

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• CD8(+) T cell differentiation: choosing a path through T-bet.

  Activated CD8(+) T cells can differentiate into transient effector cells or long-lived memory cells. In this issue of Immunity, Joshi et al. (2007) suggest that inflammatory cytokines dictate this bal…

  Authors: Sara E Hamilton, Stephen C Jameson

  Source: Immunity 2007 Aug

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