1 to 10 of 98,702 literature results

• ETS rearrangements and prostate cancer initiation.

  The first recurrent translocation event in prostate cancer has been recently described; it results in the translocation of an ETS (E26 transformation specific) transcription factor (ERG or ETV1) to th…

  Authors: Brett S Carver, Jennifer Tran, Zhenbang Chen, Arkaitz Carracedo-Perez, Andrea Alimonti, Caterina Nardella, Anuradha Gopalan, Peter T Scardino, Carlos Cordon-Cardo, William Gerald,…

  Source: Nature 2009 Feb 12

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• TMPRSS2-ERG and PTEN loss in prostate cancer.

  Two studies show that the common recurrent gene fusion between TMPRSS2 and ERG promotes prostate cancer in both mouse and humans when PTEN is concurrently lost. In human prostate cancer, the presence …

  Authors: Jeremy A Squire

  Source: Nature genetics 2009 May

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• A luminal epithelial stem cell that is a cell of origin for prostate cancer.

  In epithelial tissues, the lineage relationship between normal progenitor cells and cell type(s) of origin for cancer has been poorly understood. Here we show that a known regulator of prostate epithe…

  Authors: Xi Wang, Marianna Kruithof-de Julio, Kyriakos D Economides, David Walker, Hailong Yu, M Vivienne Halili, Ya-Ping Hu, Sandy M Price, Cory Abate-Shen, Michael M Shen

  Source: Nature 2009 Sep 24

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• Multiple loci on 8q24 associated with prostate cancer susceptibility.

  Previous studies have identified multiple loci on 8q24 associated with prostate cancer risk. We performed a comprehensive analysis of SNP associations across 8q24 by genotyping tag SNPs in 5,504 prost…

  Authors: Ali Amin Al Olama, Zsofia Kote-Jarai, Graham G Giles, Michelle Guy, Jonathan Morrison, Gianluca Severi, Daniel A Leongamornlert, Malgorzata Tymrakiewicz, Sameer Jhavar, Ed Saunders,…

  Source: Nature genetics 2009 Oct

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• Identification of a new prostate cancer susceptibility locus on chromosome 8q24.

  We report a genome-wide association study in 10,286 cases and 9,135 controls of European ancestry in the Cancer Genetic Markers of Susceptibility (CGEMS) initiative. We identify a new association with…

  Authors: Meredith Yeager, Nilanjan Chatterjee, Julia Ciampa, Kevin B Jacobs, Jesus Gonzalez-Bosquet, Richard B Hayes, Peter Kraft, Sholom Wacholder, Nick Orr, Sonja Berndt,…

  Source: Nature genetics 2009 Oct

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• Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer.

  The evolution of prostate cancer from an androgen-dependent state to one that is androgen-independent marks its lethal progression. The androgen receptor (AR) is essential in both, though its function…

  Authors: Qianben Wang, Wei Li, Yong Zhang, Xin Yuan, Kexin Xu, Jindan Yu, Zhong Chen, Rameen Beroukhim, Hongyun Wang, Mathieu Lupien,…

  Source: Cell 2009 Jul 23

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• Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression.

  Multiple, complex molecular events characterize cancer development and progression. Deciphering the molecular networks that distinguish organ-confined disease from metastatic disease may lead to the i…

  Authors: Arun Sreekumar, Laila M Poisson, Thekkelnaycke M Rajendiran, Amjad P Khan, Qi Cao, Jindan Yu, Bharathi Laxman, Rohit Mehra, Robert J Lonigro, Yong Li,…

  Source: Nature 2009 Feb 12

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• Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer.

  Many studies have shown that primary prostate cancers are multifocal and are composed of multiple genetically distinct cancer cell clones. Whether or not multiclonal primary prostate cancers typically…

  Authors: Wennuan Liu, Sari Laitinen, Sofia Khan, Mauno Vihinen, Jeanne Kowalski, Guoqiang Yu, Li Chen, Charles M Ewing, Mario A Eisenberger, Michael A Carducci,…

  Source: Nature medicine 2009 May

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• Generation of a prostate from a single adult stem cell.

  The existence of prostate stem cells (PSCs) was first postulated from the observation that normal prostate regeneration can occur after repeated cycles of androgen deprivation and replacement in roden…

  Authors: Kevin G Leong, Bu-Er Wang, Leisa Johnson, Wei-Qiang Gao

  Source: Nature 2008 Dec 11

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• Prostate cancer.

  In developed countries, prostate cancer is the second most frequently diagnosed cancer, and the third most common cause of death from cancer in men. Apart from age and ethnic origin, a positive family…

  Authors: Jan-Erik Damber, Gunnar Aus

  Source: Lancet 2008 May 17

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