1 to 10 of 12,816 literature results

• PPAR-delta senses and orchestrates clearance of apoptotic cells to promote tolerance.

  Macrophages rapidly engulf apoptotic cells to limit the release of noxious cellular contents and to restrict autoimmune responses against self antigens. Although factors participating in recognition a…

  Authors: Lata Mukundan, Justin I Odegaard, Christine R Morel, Jose E Heredia, Julia W Mwangi, Roberto R Ricardo-Gonzalez, Y P Sharon Goh, Alex Red Eagle, Shannon E Dunn, Jennifer U H Awakuni,…

  Source: Nature medicine 2009 Nov

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• PPAR-gamma regulates osteoclastogenesis in mice.

  Osteoclasts are bone-resorbing cells derived from hematopoietic precursors of the monocyte-macrophage lineage. Regulation of osteoclast function is central to the understanding of bone diseases such a…

  Authors: Yihong Wan, Ling-Wa Chong, Ronald M Evans

  Source: Nature medicine 2007 Dec

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• SUMOylation of Krüppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-delta.

  Obesity and metabolic syndrome are increasingly recognized as major risk factors for cardiovascular disease. Herein we show that Krüppel-like transcription factor 5 (KLF5) is a crucial regulator of en…

  Authors: Yumiko Oishi, Ichiro Manabe, Kazuyuki Tobe, Mitsuru Ohsugi, Tetsuya Kubota, Katsuhito Fujiu, Koji Maemura, Naoto Kubota, Takashi Kadowaki, Ryozo Nagai

  Source: Nature medicine 2008 Jun

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• Role of Jhdm2a in regulating metabolic gene expression and obesity resistance.

  Recent studies indicate that the methylation state of histones can be dynamically regulated by histone methyltransferases and demethylases. The H3K9-specific demethylase Jhdm2a (also known as Jmjd1a a…

  Authors: Keisuke Tateishi, Yuki Okada, Eric M Kallin, Yi Zhang

  Source: Nature 2009 Apr 9

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• Effect of the dual peroxisome proliferator-activated receptor-alpha/gamma agonist aleglitazar on risk of cardiovascular disease in patients with type 2 diabetes (SYNCHRONY): a phase II, randomised, dose-ranging study.

  BACKGROUND: Despite previous reports of potential adverse cardiovascular effects of peroxisome proliferator-activated receptor (PPAR) agonists, the promise for PPAR agonists to positively affect risk …

  Authors: Robert R Henry, A Michael Lincoff, Sunder Mudaliar, Michael Rabbia, Cathy Chognot, Matthias Herz

  Source: Lancet 2009 Jul 11

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• Regulation of skeletal muscle physiology and metabolism by peroxisome proliferator-activated receptor delta.

  Agonists directed against the alpha and gamma isoforms of the peroxisome proliferator-activated receptors (PPARs) have become important for the respective treatment of hypertriglyceridemia and insulin…

  Authors: Ewa Ehrenborg, Anna Krook

  Source: Pharmacological reviews 2009 Sep

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• Single nucleotide polymorphisms of the peroxisome proliferator-activated receptor-alpha gene (PPARA) influence the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial.

  Peroxisome proliferator-activated receptor (PPAR) alpha, a transcription factor of the nuclear receptor superfamily, regulates fatty acid oxidation. We evaluated the association of single nucleotide p…

  Authors: Laura Andrulionyte, Teemu Kuulasmaa, Jean-Louis Chiasson, Markku Laakso, STOP-NIDDM Study Group

  Source: Diabetes 2007 Apr

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• A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma.

  Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) has essential roles in adipogenesis and glucose homeostasis, and is a molecular target of insulin-sensitizing drugs. Although the ability …

  Authors: Gabriel Pascual, Amy L Fong, Sumito Ogawa, Amir Gamliel, Andrew C Li, Valentina Perissi, David W Rose, Timothy M Willson, Michael G Rosenfeld, Christopher K Glass

  Source: Nature 2005 Sep 29

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• Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA.

  Nuclear receptors are multi-domain transcription factors that bind to DNA elements from which they regulate gene expression. The peroxisome proliferator-activated receptors (PPARs) form heterodimers w…

  Authors: Vikas Chandra, Pengxiang Huang, Yoshitomo Hamuro, Srilatha Raghuram, Yongjun Wang, Thomas P Burris, Fraydoon Rastinejad

  Source: Nature 2008 Nov 20

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• Structure of the intact PPAR-gamma-RXR-alpha nuclear receptor complex on DNA.

  Nuclear receptors are multi-domain transcription factors that bind to DNA elements from which they regulate gene expression. The peroxisome proliferator-activated receptors (PPARs) form heterodimers w…

  Authors: Vikas Chandra, Pengxiang Huang, Yoshitomo Hamuro, Srilatha Raghuram, Yongjun Wang, Thomas P Burris, Fraydoon Rastinejad

  Source: Nature 2008 Oct 29

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