1 to 10 of 66,266 literature results

• TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus.

  Glucocorticoids are widely used to treat patients with autoimmune diseases such as systemic lupus erythematosus (SLE). However, regimens used to treat many such conditions cannot maintain disease ...

  Authors: Cristiana Guiducci, Mei Gong, Zhaohui Xu, Michelle Gill, Damien Chaussabel, Thea Meeker, Jean H Chan, Tracey Wright, Marilynn Punaro, Silvia Bolland,…

  Source: Nature 2010 Jun 17

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• Neurotoxic autoantibodies mediate congenital cortical impairment of offspring in maternal lupus.

  Systemic lupus erythematosus (SLE) is an autoimmune disease mediated by autoantibodies and preferentially affecting women of childbearing age. Because the offspring of mothers with SLE show a high ...

  Authors: Ji Y Lee, Patricio T Huerta, Jie Zhang, Czeslawa Kowal, Eva Bertini, Bruce T Volpe, Betty Diamond

  Source: Nature medicine 2009 Jan

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• Advances in lupus stemming from the parent-into-F1 model.

  The parent-into-F1 model has led to important advances in our understanding of lupus. Here, we review the work in murine lupus that elucidated the role of T cells and supported the conclusion ...

  Authors: Charles S Via

  Source: Trends in immunology 2010 Jun

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• Innate immune response triggers lupus-like autoimmune disease.

  Autoimmune disease is typically defined as an aberrant response of lymphocytes to self antigens that ultimately leads to tissue damage. Reporting in Immunity, Green et al. (2007) now show that mice la ...

  Authors: James C Paulson

  Source: Cell 2007 Aug 24

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• The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis.

  Autoantibody-mediated diseases like myasthenia gravis, autoimmune hemolytic anemia and systemic lupus erythematosus represent a therapeutic challenge. In particular, long-lived plasma cells producing ...

  Authors: Kirsten Neubert, Silke Meister, Katrin Moser, Florian Weisel, Damian Maseda, Kerstin Amann, Carsten Wiethe, Thomas H Winkler, Joachim R Kalden, Rudolf A Manz,…

  Source: Nature medicine 2008 Jul

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• Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry.

  The origins of autoimmunity in systemic lupus erythematosus (SLE) are thought to involve both genetic and environmental factors. To identify environmental agents that could potentially incite ...

  Authors: Micah T McClain, Latisha D Heinlen, Gregory J Dennis, Jon Roebuck, John B Harley, Judith A James

  Source: Nature medicine 2005 Jan

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• Understanding lupus: fishing genes out of mice and men.

  In this issue of Immunity, the Coronin-1A gene Coro1a, which regulates cytoskeletal structure, is shown by Haraldsson et al. (2007) to be a surprising disease-susceptibility gene that contributes to t ...

  Authors: Tim J Vyse

  Source: Immunity 2008 Jan

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• Basophils and the T helper 2 environment can promote the development of lupus nephritis.

  In systemic lupus erythematosus (SLE), self-reactive antibodies can target the kidney (lupus nephritis), leading to functional failure and possible mortality. We report that activation of basophils ...

  Authors: Nicolas Charles, Donna Hardwick, Eric Daugas, Gabor G Illei, Juan Rivera

  Source: Nature medicine 2010 Jun

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• Pseudoviral immunity - a novel concept for lupus.

  Systemic lupus erythematosus (SLE or lupus) is a polygenic syndrome of immunity against nuclear autoantigens. Recent data from several fields now suggest 'pseudoviral' immunity as a novel disease ...

  Authors: Hans-Joachim Anders

  Source: Trends in molecular medicine 2009 Dec

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• Activated basophils give lupus a booster shot.

  Authors: Anne Davidson, Betty Diamond

  Source: Nature medicine 2010 Jun

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