1 to 10 of 59,257 literature results

• Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus.

  Systemic lupus erythematosus (SLE) is an autoimmune disease influenced by genetic and environmental factors. We carried out a genome-wide association scan and replication study and found an associatio…

  Authors: Robert R Graham, Chris Cotsapas, Leela Davies, Rachel Hackett, Christopher J Lessard, Joanlise M Leon, Noel P Burtt, Candace Guiducci, Melissa Parkin, Casey Gates,…

  Source: Nature genetics 2008 Sep

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• Neurotoxic autoantibodies mediate congenital cortical impairment of offspring in maternal lupus.

  Systemic lupus erythematosus (SLE) is an autoimmune disease mediated by autoantibodies and preferentially affecting women of childbearing age. Because the offspring of mothers with SLE show a high fre…

  Authors: Ji Y Lee, Patricio T Huerta, Jie Zhang, Czeslawa Kowal, Eva Bertini, Bruce T Volpe, Betty Diamond

  Source: Nature medicine 2009 Jan

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• The role of complement in the development of systemic lupus erythematosus.

  Complement has both beneficial and deleterious roles in the pathogenesis of systemic lupus erythematosus (SLE). On the one hand, patients with SLE present with decreased complement levels and with com…

  Authors: Anthony P Manderson, Marina Botto, Mark J Walport

  Source: Annual review of immunology 2004

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• Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus.

  Systemic lupus erythematosus (SLE) is an autoimmune disease influenced by genetic and environmental factors. We carried out a genome-wide association scan and replication study and found an associatio…

  Authors: Robert R Graham, Chris Cotsapas, Leela Davies, Rachel Hackett, Christopher J Lessard, Joanlise M Leon, Noel P Burtt, Candace Guiducci, Melissa Parkin, Casey Gates,…

  Source: Nature genetics 2008 Aug 1

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• Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus.

  The TNFAIP3 (tumor necrosis factor alpha-induced protein 3) gene encodes a ubiquitin editing enzyme, A20, that restricts NF-kappaB-dependent signaling and prevents inflammation. We show that three ind…

  Authors: Stacy L Musone, Kimberly E Taylor, Timothy T Lu, Joanne Nititham, Ricardo C Ferreira, Ward Ortmann, Nataliya Shifrin, Michelle A Petri, M Ilyas Kamboh, Susan Manzi,…

  Source: Nature genetics 2008 Aug 1

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• Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus.

  The TNFAIP3 (tumor necrosis factor alpha-induced protein 3) gene encodes a ubiquitin editing enzyme, A20, that restricts NF-kappaB-dependent signaling and prevents inflammation. We show that three ind…

  Authors: Stacy L Musone, Kimberly E Taylor, Timothy T Lu, Joanne Nititham, Ricardo C Ferreira, Ward Ortmann, Nataliya Shifrin, Michelle A Petri, M Ilyas Kamboh, Susan Manzi,…

  Source: Nature genetics 2008 Sep

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• Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus.

  Systemic lupus erythematosus (SLE) is a multisystem complex autoimmune disease of uncertain etiology (OMIM 152700). Over recent years a genetic component to SLE susceptibility has been established. Re…

  Authors: Deborah S Cunninghame Graham, Robert R Graham, Harinder Manku, Andrew K Wong, John C Whittaker, Patrick M Gaffney, Kathy L Moser, John D Rioux, David Altshuler, Timothy W Behrens,…

  Source: Nature genetics 2008 Jan

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• Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.

  We performed a genome-wide association study (GWAS) of systemic lupus erythematosus (SLE) in a Chinese Han population by genotyping 1,047 cases and 1,205 controls using Illumina Human610-Quad BeadChip…

  Authors: Jian-Wen Han, Hou-Feng Zheng, Yong Cui, Liang-Dan Sun, Dong-Qing Ye, Zhi Hu, Jin-Hua Xu, Zhi-Ming Cai, Wei Huang, Guo-Ping Zhao,…

  Source: Nature genetics 2009 Nov

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• Interleukin 17 acts in synergy with B cell-activating factor to influence B cell biology and the pathophysiology of systemic lupus erythematosus.

  Studies have suggested involvement of interleukin 17 (IL-17) in autoimmune diseases, although its effect on B cell biology has not been clearly established. Here we demonstrate that IL-17 alone or in …

  Authors: Agnès Doreau, Alexandre Belot, Jérémy Bastid, Benjamin Riche, Marie-Claude Trescol-Biemont, Bruno Ranchin, Nicole Fabien, Pierre Cochat, Claire Pouteil-Noble, Pierre Trolliet,…

  Source: Nature immunology 2009 Jul

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• Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus.

  Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease characterized by production of autoantibodies and complex genetic inheritance. In a genome-wide scan using 85,042 SNPs, we ident…

  Authors: Sergey V Kozyrev, Anna-Karin Abelson, Jerome Wojcik, Ammar Zaghlool, M V Prasad Linga Reddy, Elena Sanchez, Iva Gunnarsson, Elisabet Svenungsson, Gunnar Sturfelt, Andreas Jönsen,…

  Source: Nature genetics 2008 Feb

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