1 to 10 of 167,459 literature results

• Flying under the radar: the immunobiology of hepatitis C.

  The hepatitis C virus (HCV) is a remarkably successful pathogen, establishing persistent infection in more than two-thirds of those who contract it. Its success is related to its abilities to blunt in…

  Authors: Lynn B Dustin, Charles M Rice

  Source: Annual review of immunology 2007

  View Full Text

• Induction of hepatitis by JNK-mediated expression of TNF-alpha.

  The c-Jun NH(2)-terminal kinase (JNK) signaling pathway has been implicated in the development of tumor necrosis factor (TNF)-dependent hepatitis. JNK may play a critical role in hepatocytes during TN…

  Authors: Madhumita Das, Guadalupe Sabio, Feng Jiang, Mercedes Rincón, Richard A Flavell, Roger J Davis

  Source: Cell 2009 Jan 23

  View Full Text

• Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance.

  Chronic infection with hepatitis C virus (HCV) affects 170 million people worldwide and is the leading cause of cirrhosis in North America. Although the recommended treatment for chronic infection inv…

  Authors: Dongliang Ge, Jacques Fellay, Alexander J Thompson, Jason S Simon, Kevin V Shianna, Thomas J Urban, Erin L Heinzen, Ping Qiu, Arthur H Bertelsen, Andrew J Muir,…

  Source: Nature 2009 Sep 17

  View Full Text

• Human occludin is a hepatitis C virus entry factor required for infection of mouse cells.

  Hepatitis C virus (HCV) is a leading cause of liver disease worldwide. The development of much needed specific antiviral therapies and an effective vaccine has been hampered by the lack of a convenien…

  Authors: Alexander Ploss, Matthew J Evans, Valeriya A Gaysinskaya, Maryline Panis, Hana You, Ype P de Jong, Charles M Rice

  Source: Nature 2009 Feb 12

  View Free Full Text

• Decreased levels of microRNA miR-122 in individuals with hepatitis C responding poorly to interferon therapy.

  Several microRNAs (miRNAs), including liver-specific miR-122, have been implicated in the control of hepatitis C virus (HCV) RNA replication and its response to interferon (IFN) in human hepatoma cell…

  Authors: Magdalena Sarasin-Filipowicz, Jacek Krol, Ilona Markiewicz, Markus H Heim, Witold Filipowicz

  Source: Nature medicine 2009 Jan

  View Full Text

• Genetic variation in IL28B and spontaneous clearance of hepatitis C virus.

  Hepatitis C virus (HCV) infection is the most common blood-borne infection in the United States, with estimates of 4 million HCV-infected individuals in the United States and 170 million worldwide. Mo…

  Authors: David L Thomas, Chloe L Thio, Maureen P Martin, Ying Qi, Dongliang Ge, Colm O'huigin, Judith Kidd, Kenneth Kidd, Salim I Khakoo, Graeme Alexander,…

  Source: Nature 2009 Sep 16

  View Full Text

• Aggravation of viral hepatitis by platelet-derived serotonin.

  More than 500 million people worldwide are persistently infected with hepatitis B virus or hepatitis C virus. Although both viruses are poorly cytopathic, persistence of either virus carries a risk of…

  Authors: Philipp A Lang, Claudio Contaldo, Panco Georgiev, Ashraf Mohammad El-Badry, Mike Recher, Michael Kurrer, Luisa Cervantes-Barragan, Burkhard Ludewig, Thomas Calzascia, Beatrice Bolinger,…

  Source: Nature medicine 2008 Jul

  View Full Text

• Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge.

  A major problem in hepatitis C virus (HCV) immunotherapy or vaccine design is the extreme variability of the virus. We identified human monoclonal antibodies (mAbs) that neutralize genetically diverse…

  Authors: Mansun Law, Toshiaki Maruyama, Jamie Lewis, Erick Giang, Alexander W Tarr, Zania Stamataki, Pablo Gastaminza, Francis V Chisari, Ian M Jones, Robert I Fox,…

  Source: Nature medicine 2008 Jan

  View Full Text

• Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA.

  Innate immune defences are essential for the control of virus infection and are triggered through host recognition of viral macromolecular motifs known as pathogen-associated molecular patterns (PAMPs…

  Authors: Takeshi Saito, David M Owen, Fuguo Jiang, Joseph Marcotrigiano, Michael Gale

  Source: Nature 2008 Jul 24

  View Full Text

• A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians.

  Chronic hepatitis B is a serious infectious liver disease that often progresses to liver cirrhosis and hepatocellular carcinoma; however, clinical outcomes after viral exposure vary enormously among i…

  Authors: Yoichiro Kamatani, Sukanya Wattanapokayakit, Hidenori Ochi, Takahisa Kawaguchi, Atsushi Takahashi, Naoya Hosono, Michiaki Kubo, Tatsuhiko Tsunoda, Naoyuki Kamatani, Hiromitsu Kumada,…

  Source: Nature genetics 2009 May

  View Full Text