1 to 10 of 2,019 literature results

• Mutations in the fatty acid 2-hydroxylase gene are associated with leukodystrophy with spastic paraparesis and dystonia.

  Myelination is a complex, developmentally regulated process whereby myelin proteins and lipids are coordinately expressed by myelinating glial cells. Homozygosity mapping in nine patients with childho…

  Authors: Simon Edvardson, Hiroko Hama, Avraham Shaag, John Moshe Gomori, Itai Berger, Dov Soffer, Stanley H Korman, Ilana Taustein, Ann Saada, Orly Elpeleg

  Source: American journal of human genetics 2008 Nov

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• Fatty acid oxidation disorders.

  Genetic disorders of mitochondrial fatty acid beta-oxidation have been recognized within the last 20 years as important causes of morbidity and mortality, highlighting the physiological significance o…

  Authors: Piero Rinaldo, Dietrich Matern, Michael J Bennett

  Source: Annual review of physiology 2002

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• Cdk1/Cdc28-dependent activation of the major triacylglycerol lipase Tgl4 in yeast links lipolysis to cell-cycle progression.

  Triacylglycerols (TGs) serve essential cellular functions as reservoirs for energy substrates (fatty acids) and membrane lipid precursors (diacylglycerols and fatty acids). Here we show that the major…

  Authors: Christoph F Kurat, Heimo Wolinski, Julia Petschnigg, Supipi Kaluarachchi, Brenda Andrews, Klaus Natter, Sepp D Kohlwein

  Source: Molecular cell 2009 Jan 16

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• Fatty acid-induced mitochondrial uncoupling in adipocytes as a key protective factor against insulin resistance and beta cell dysfunction: a new concept in the pathogenesis of obesity-associated type 2 diabetes mellitus.

  Type 2 diabetes is associated with excessive food intake and a sedentary lifestyle. Local inflammation of white adipose tissue induces cytokine-mediated insulin resistance of adipocytes. This results …

  Authors: J A Maassen, J A Romijn, R J Heine

  Source: Diabetologia 2007 Oct

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• Alterations in microRNA expression contribute to fatty acid-induced pancreatic beta-cell dysfunction.

  OBJECTIVE: Visceral obesity and elevated plasma free fatty acids are predisposing factors for type 2 diabetes. Chronic exposure to these lipids is detrimental for pancreatic beta-cells, resulting in r…

  Authors: Pascal Lovis, Elodie Roggli, D Ross Laybutt, Sonia Gattesco, Jiang-Yan Yang, Christian Widmann, Amar Abderrahmani, Romano Regazzi

  Source: Diabetes 2008 Oct

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• Genome-scale models of bacterial metabolism: reconstruction and applications.

  Genome-scale metabolic models bridge the gap between genome-derived biochemical information and metabolic phenotypes in a principled manner, providing a solid interpretative framework for experimental…

  Authors: Maxime Durot, Pierre-Yves Bourguignon, Vincent Schachter

  Source: FEMS microbiology reviews 2009 Jan

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• Metabolic targeting of cancers: from molecular mechanisms to therapeutic strategies.

  Multiple lines of evidence shows that tumorigenesis is often associated with altered carbohydrate metabolism, characterized by increased glucose uptake and elevated glycolysis, which was first recogni…

  Authors: Huaming Sheng, Ben Niu, Hongbin Sun

  Source: Current medicinal chemistry 2009

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• Type II fatty acid synthesis is essential only for malaria parasite late liver stage development.

  Intracellular malaria parasites require lipids for growth and replication. They possess a prokaryotic type II fatty acid synthesis (FAS II) pathway that localizes to the apicoplast plastid organelle a…

  Authors: Ashley M Vaughan, Matthew T O'Neill, Alice S Tarun, Nelly Camargo, Thuan M Phuong, Ahmed S I Aly, Alan F Cowman, Stefan H I Kappe

  Source: Cellular microbiology 2009 Mar

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• Pseudomonas aeruginosa twitching motility-mediated chemotaxis towards phospholipids and fatty acids: specificity and metabolic requirements.

  Pseudomonas aeruginosa demonstrates type IV pilus-mediated directional twitching motility up a gradient of phosphatidylethanolamine (PE). Only one of four extracellular phospholipases C of P. aerugino…

  Authors: Rhea M Miller, Andrew P Tomaras, Adam P Barker, Dennis R Voelker, Edward D Chan, Adriana I Vasil, Michael L Vasil

  Source: Journal of bacteriology 2008 Jun

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• Fatty acid transport across membranes: relevance to nutrition and metabolic pathology.

  Long-chain fatty acids are an important constituent of the diet and they contribute to a multitude of cellular pathways and functions. Uptake of long-chain fatty acids across plasma membranes is the f…

  Authors: Tahar Hajri, Nada A Abumrad

  Source: Annual review of nutrition 2002

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