1 to 10 of 2,605 literature results

• Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2.

  Adipocyte fatty-acid-binding protein, aP2 (FABP4) is expressed in adipocytes and macrophages, and integrates inflammatory and metabolic responses. Studies in aP2-deficient mice have shown that this li…

  Authors: Masato Furuhashi, Gürol Tuncman, Cem Z Görgün, Liza Makowski, Genichi Atsumi, Eric Vaillancourt, Keita Kono, Vladimir R Babaev, Sergio Fazio, MacRae F Linton,…

  Source: Nature 2007 Jun 21

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• L-FABP directly interacts with PPARalpha in cultured primary hepatocytes.

  Although studies with liver type fatty acid binding protein (L-FABP) gene ablated mice demonstrate a physiological role for L-FABP in hepatic fatty acid metabolism, little is known about the mechanism…

  Authors: Heather A Hostetler, Avery L McIntosh, Barbara P Atshaves, Stephen M Storey, H Ross Payne, Ann B Kier, Friedhelm Schroeder

  Source: Journal of lipid research 2009 Aug

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• Differential proteomic analysis of STAT6 knockout mice reveals new regulatory function in liver lipid homeostasis.

  Increased inflammatory signaling is a key feature of metabolic disorders. In this context, the role of increased pro-inflammatory signals has been extensively studied. By contrast, no efforts have bee…

  Authors: Joël Iff, Wei Wang, Tatjana Sajic, Nathalie Oudry, Estelle Gueneau, Gérard Hopfgartner, Emmanuel Varesio, Ildiko Szanto

  Source: Journal of proteome research 2009 Oct

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• Prognostic utility of heart-type fatty acid binding protein in patients with acute coronary syndromes.

  BACKGROUND: Heart-type fatty acid binding protein (H-FABP) is a cytosolic protein that is released rapidly from the cardiomyocyte in response to myocardial injury. Although it has been investigated as…

  Authors: Michelle O'Donoghue, James A de Lemos, David A Morrow, Sabina A Murphy, Jacqueline L Buros, Christopher P Cannon, Marc S Sabatine

  Source: Circulation 2006 Aug 8

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• Characterization of the drug binding specificity of rat liver fatty acid binding protein.

  Liver-fatty acid binding protein (L-FABP) is found in high levels in enterocytes and is involved in the cytosolic solubilization of fatty acids during fat absorption. In the current studies, the inter…

  Authors: Sara Chuang, Tony Velkov, James Horne, Christopher J H Porter, Martin J Scanlon

  Source: Journal of medicinal chemistry 2008 Jul 10

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• Structural basis for activation of fatty acid-binding protein 4.

  Fatty acid-binding protein 4 (FABP4) delivers ligands from the cytosol to the nuclear receptor PPARgamma in the nucleus, thereby enhancing the transcriptional activity of the receptor. Notably, FABP4 …

  Authors: Richard E Gillilan, Stephen D Ayers, Noa Noy

  Source: Journal of molecular biology 2007 Oct 5

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• Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis.

  The adipocyte fatty-acid-binding protein, aP2, has an important role in regulating systemic insulin resistance and lipid metabolism. Here we demonstrate that aP2 is also expressed in macrophages, has …

  Authors: L Makowski, J B Boord, K Maeda, V R Babaev, K T Uysal, M A Morgan, R A Parker, J Suttles, S Fazio, G S Hotamisligil,…

  Source: Nature medicine 2001 Jun

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• Molecular mechanism of recombinant liver fatty acid binding protein's antioxidant activity.

  Hepatocytes expressing liver fatty acid binding protein (L-FABP) are known to be more resistant to oxidative stress than those devoid of this protein. The mechanism for the observed antioxidant activi…

  Authors: Jing Yan, Yuewen Gong, Yi-Min She, Guqi Wang, Michael S Roberts, Frank J Burczynski

  Source: Journal of lipid research 2009 May 27

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• Gata4 is essential for the maintenance of jejunal-ileal identities in the adult mouse small intestine.

  Gata4, a member of the zinc finger family of GATA transcription factors, is highly expressed in duodenum and jejunum but is nearly undetectable in distal ileum of adult mice. We show here that the cau…

  Authors: Tjalling Bosse, Christina M Piaseckyj, Ellen Burghard, John J Fialkovich, Satish Rajagopal, William T Pu, Stephen D Krasinski

  Source: Molecular and cellular biology 2006 Dec

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• Plasma fatty acid-binding protein 4 increases with renal dysfunction in type 2 diabetic patients without microalbuminuria.

  BACKGROUND: Fatty acid-binding protein 4 (FABP4) has been linked to metabolic syndrome development, diabetes, and arteriosclerosis, but the role of FABP4 in target organ damage has not been assessed. …

  Authors: Anna Cabré, Iolanda Lázaro, Josefa Girona, Josep M Manzanares, Francesc Marimón, Núria Plana, Mercedes Heras, Lluís Masana

  Source: Clinical chemistry 2008 Jan

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