1 to 10 of 134,239 literature results

• Endothelial cells form a phalanx to block tumor metastasis.

  Tumor blood vessels deliver oxygen poorly, thereby contributing to tumor hypoxia and upregulation of proangiogenic cytokines in an escalating feedback loop. Mazzone et al. (2009) now show that reducin…

  Authors: Victoria L Bautch

  Source: Cell 2009 Mar 6

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• Kindlin-3 is required for beta2 integrin-mediated leukocyte adhesion to endothelial cells.

  Integrin activation is essential for the function of all blood cells, including platelets and leukocytes. The blood cell-specific FERM domain protein Kindlin-3 is required for the activation of the be…

  Authors: Markus Moser, Martina Bauer, Stephan Schmid, Raphael Ruppert, Sarah Schmidt, Michael Sixt, Hao-Ven Wang, Markus Sperandio, Reinhard Fässler

  Source: Nature medicine 2009 Mar

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• Norrin, frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization.

  Disorders of vascular structure and function play a central role in a wide variety of CNS diseases. Mutations in the Frizzled-4 (Fz4) receptor, Lrp5 coreceptor, or Norrin ligand cause retinal hypovasc…

  Authors: Xin Ye, Yanshu Wang, Hugh Cahill, Minzhong Yu, Tudor C Badea, Philip M Smallwood, Neal S Peachey, Jeremy Nathans

  Source: Cell 2009 Oct 16

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• T lymphocyte-endothelial cell interactions.

  Human vascular endothelial cells (EC) basally display class I and II MHC-peptide complexes on their surface and come in regular contact with circulating T cells. We propose that EC present microbial a…

  Authors: Jaehyuk Choi, David R Enis, Kian Peng Koh, Stephen L Shiao, Jordan S Pober

  Source: Annual review of immunology 2004

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• Master and commander: continued expression of Prox1 prevents the dedifferentiation of lymphatic endothelial cells.

  Cell differentiation occurs mostly during a specific developmental time window and is irreversible. The homeobox-containing transcription factor Prox1 is a master regulator of lymphatic endothelial ce…

  Authors: M Gabriele Bixel, Ralf H Adams

  Source: Genes & development 2008 Dec 1

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• Dendritic cell-endothelial cell cross-talk in angiogenesis.

  Dendritic cells (DCs) are professional antigen-presenting cells that have a pivotal role in the onset and regulation of adaptive immune responses. DCs have the ability to regulate inflammation through…

  Authors: Silvano Sozzani, Marco Rusnati, Elena Riboldi, Stefania Mitola, Marco Presta

  Source: Trends in immunology 2007 Sep

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• Lymphatic endothelial cell identity is reversible and its maintenance requires Prox1 activity.

  The activity of the homeobox gene Prox1 is necessary and sufficient for venous blood endothelial cells (BECs) to acquire a lymphatic endothelial cell (LEC) fate. We determined that the differentiated …

  Authors: Nicole C Johnson, Miriam E Dillard, Peter Baluk, Donald M McDonald, Natasha L Harvey, Sharon L Frase, Guillermo Oliver

  Source: Genes & development 2008 Dec 1

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• Peptide hormone regulation of angiogenesis.

  It is now apparent that regulation of blood vessel growth contributes to the classical actions of hormones on development, growth, and reproduction. Endothelial cells are ideally positioned to respond…

  Authors: Carmen Clapp, Stéphanie Thebault, Michael C Jeziorski, Gonzalo Martínez De La Escalera

  Source: Physiological reviews 2009 Oct

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• Transcriptional control of endothelial cell development.

  The transcription factors that regulate endothelial cell development have been a focus of active research for several years, and many players in the endothelial transcriptional program have been ident…

  Authors: Sarah De Val, Brian L Black

  Source: Developmental cell 2009 Feb

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• Endothelial cells and VEGF in vascular development.

  The intricate patterning processes that establish the complex vascular system during development depend on a combination of intrinsic pre-patterning and extrinsic responses to environmental parameters…

  Authors: Leigh Coultas, Kallayanee Chawengsaksophak, Janet Rossant

  Source: Nature 2005 Dec 15

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