1 to 10 of 4,778 literature results

• Proteomic characterization of the effects of clofibrate on protein expression in rat liver.

  Clofibrate is a peroxisome proliferator known to induce liver tumours in rats. A proteomics study was conducted to provide new insights into the molecular mechanisms of clofibrate-induced non-genotoxi…

  Authors: Jean-François Léonard, Martine Courcol, Claire Mariet, Aurore Charbonnier, Eric Boitier, Marc Duchesne, Fabienne Parker, Bruno Genet, Françoise Supatto, Ruth Roberts,…

  Source: Proteomics 2006 Mar

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• Mechanisms of clofibrate-induced apoptosis in Yoshida AH-130 hepatoma cells.

  Peroxisome proliferators (PPs) are a class of compounds that exert their nominal effects through the peroxisome proliferator-activated receptors. PPs, among which clofibrate (CF), have been extensivel…

  Authors: F Penna, P Reffo, G Muzio, R A Canuto, F M Baccino, G Bonelli, P Costelli

  Source: Biochemical pharmacology 2009 Jan 15

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• Clofibrate prevents and reverses the hemodynamic manifestations of hyperthyroidism in rats.

  BACKGROUND: This study analyzed the effects of the chronic administration of clofibrate, a peroxisome proliferator-activated receptor-alpha (PPARalpha) agonist, on the development and established hemo…

  Authors: Isabel Rodríguez-Gómez, Antonio Cruz, Juan Manuel Moreno, Agatángelo Soler, Antonio Osuna, Félix Vargas

  Source: American journal of hypertension 2008 Mar

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• Clofibrate and gemfibrozil induce an embryonic malabsorption syndrome in zebrafish.

  Nutrient availability is one of the major non-genetic factors determining embryonic growth and larval or fetal size. Due to the high human consumption of blood lipid regulators, fibrates have recently…

  Authors: Demetrio Raldúa, Michèle André, Patrick J Babin

  Source: Toxicology and applied pharmacology 2008 May 1

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• KazrinE is a desmosome-associated liprin that colocalises with acetylated microtubules.

  Kazrin is a widely expressed, evolutionarily conserved cytoplasmic protein that binds the cytolinker protein periplakin. Multiple functions of kazrin have been reported, including regulation of desmos…

  Authors: Rachida Nachat, Sara Cipolat, Lisa M Sevilla, Mariya Chhatriwala, Karen R Groot, Fiona M Watt

  Source: Journal of cell science 2009 Nov 15

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• SYD-2 Liprin-alpha organizes presynaptic active zone formation through ELKS.

  A central event in synapse development is formation of the presynaptic active zone in response to positional cues. Three active zone proteins, RIM, ELKS (also known as ERC or CAST) and Liprin-alpha, b…

  Authors: Ya Dai, Hidenori Taru, Scott L Deken, Brock Grill, Brian Ackley, Michael L Nonet, Yishi Jin

  Source: Nature neuroscience 2006 Dec

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• Differential gene expression in mouse liver associated with the hepatoprotective effect of clofibrate.

  Pretreatment of mice with the peroxisome proliferator clofibrate (CFB) protects against acetaminophen (APAP)-induced hepatotoxicity. Previous studies have shown that activation of the nuclear peroxiso…

  Authors: Jeffrey S Moffit, Petra H Koza-Taylor, Ricky D Holland, Michael S Thibodeau, Richard D Beger, Michael P Lawton, José E Manautou

  Source: Toxicology and applied pharmacology 2007 Jul 15

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• Nonalcoholic steatohepatitic (NASH) mice are protected from higher hepatotoxicity of acetaminophen upon induction of PPARalpha with clofibrate.

  The objective was to investigate if the hepatotoxic sensitivity in nonalcoholic steatohepatitic mice to acetaminophen (APAP) is due to downregulation of nuclear receptor PPARalpha via lower cell divis…

  Authors: Shashikiran Donthamsetty, Vishakha S Bhave, Mayurranjan S Mitra, John R Latendresse, Harihara M Mehendale

  Source: Toxicology and applied pharmacology 2008 Aug 1

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• Colfibrate attenuates blood pressure and sodium retention in DOCA-salt hypertension.

  Clofibrate, a peroxisome proliferator-activated receptor-alpha (PPAR alpha) agonist, increases renal tubular cytochrome P450 4a (Cyp4a) expression thereby increasing 20-hydroxyeicosatetraenoic acid (2…

  Authors: Yiqiang Zhou, Pengcheng Luo, Hsin-Hsin Chang, Hui Huang, Tianxin Yang, Zheng Dong, Cong-Yi Wang, Mong-Heng Wang

  Source: Kidney international 2008 Oct

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• LAR, liprin alpha and the regulation of active zone morphogenesis.

  Active zones are protein-rich regions of neurons that act as sites of synaptic vesicle fusion and neurotransmitter release at the pre-synaptic terminus. Although the discovery that the receptor protei…

  Authors: Emily Stryker, Karl G Johnson

  Source: Journal of cell science 2007 Nov 1

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