1 to 10 of 7,948 literature results

• MERIT40 facilitates BRCA1 localization and DNA damage repair.

  The product of breast cancer susceptibility gene 1, BRCA1, plays pivotal roles in the maintenance of genomic integrity. Mounting evidence indicates that BRCA1 associates with many proteins or protein …

  Authors: Lin Feng, Jun Huang, Junjie Chen

  Source: Genes & development 2009 Mar 15

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• Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers.

  Basal-like breast cancers arising in women carrying mutations in the BRCA1 gene, encoding the tumor suppressor protein BRCA1, are thought to develop from the mammary stem cell. To explore early cellul…

  Authors: Elgene Lim, François Vaillant, Di Wu, Natasha C Forrest, Bhupinder Pal, Adam H Hart, Marie-Liesse Asselin-Labat, David E Gyorki, Teresa Ward, Audrey Partanen,…

  Source: Nature medicine 2009 Aug

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• The XIST noncoding RNA functions independently of BRCA1 in X inactivation.

  Females with germline mutations in BRCA1 are predisposed to develop breast and ovarian cancers. A previous report indicated that BRCA1 colocalizes with and is necessary for the correct localization of…

  Authors: Cuiying Xiao, Judith A Sharp, Misako Kawahara, Albert R Davalos, Michael J Difilippantonio, Ying Hu, Wenmei Li, Liu Cao, Ken Buetow, Thomas Ried,…

  Source: Cell 2007 Mar 9

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• Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis.

  Germline mutations of BRCA1 predispose women to breast and ovarian cancers. However, the downstream mediators of BRCA1 function in tumor suppression remain elusive. We found that human BRCA1-associate…

  Authors: Rui-Hong Wang, Yin Zheng, Hyun-Seok Kim, Xiaoling Xu, Liu Cao, Tyler Luhasen, Mi-Hye Lee, Cuiying Xiao, Athanassios Vassilopoulos, Weiping Chen,…

  Source: Molecular cell 2008 Oct 10

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• A mitotic role for BRCA1/BARD1 in tumor suppression?

  The tumor-suppressor protein BRCA1 is thought to act by preserving genomic integrity. In this issue of Cell, Joukov et al. demonstrate that the BRCA1/BARD1 heterodimer participates in mitotic spindle …

  Authors: Paul R Clarke, Helen S Sanderson

  Source: Cell 2006 Nov 3

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• The BRCA1/BARD1 heterodimer modulates ran-dependent mitotic spindle assembly.

  The heterodimeric tumor-suppressor complex BRCA1/BARD1 exhibits E3 ubiquitin ligase activity and participates in cell proliferation and chromosome stability control by incompletely defined mechanisms.…

  Authors: Vladimir Joukov, Aaron C Groen, Tatyana Prokhorova, Ruth Gerson, Erinn White, Alison Rodriguez, Johannes C Walter, David M Livingston

  Source: Cell 2006 Nov 3

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• A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency.

  The molecular pathways leading from genomic instability to cellular senescence and/or cell death remain incompletely characterized. Using mouse embryonic fibroblasts with constitutively increased DNA …

  Authors: Liu Cao, Xioaling Xu, Samuel F Bunting, Jie Liu, Rui-Hong Wang, Longyue L Cao, J Julie Wu, Tie-Nan Peng, Junjie Chen, Andre Nussenzweig,…

  Source: Molecular cell 2009 Aug 28

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• NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control.

  The ability to sense and respond to DNA damage is critical to maintenance of genomic stability and the prevention of cancer. In this study, we employed a genetic screen to identify a gene, NBA1 (new c…

  Authors: Bin Wang, Kristen Hurov, Kay Hofmann, Stephen J Elledge

  Source: Genes & development 2009 Mar 15

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• BRCA1--sowing the seeds crooked in the furrow.

  Breast tumors with deficiency in DNA double-strand break repair might be expected to show aneuploidy. A new study shows that microdeletions in PTEN, resulting in complete loss of PTEN protein, are sig…

  Authors: William D Foulkes

  Source: Nature genetics 2008 Jan

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• Meta-analysis of risk reduction estimates associated with risk-reducing salpingo-oophorectomy in BRCA1 or BRCA2 mutation carriers.

  BACKGROUND: Risk-reducing salpingo-oophorectomy (RRSO) is widely used by carriers of BRCA1 or BRCA2 (BRCA1/2) mutations to reduce their risks of breast and ovarian cancer. To guide women and their cli…

  Authors: Timothy R Rebbeck, Noah D Kauff, Susan M Domchek

  Source: Journal of the National Cancer Institute 2009 Jan 21

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