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Efficacy and Safety of Imatinib in Chordoma


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  • Purpose

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    Preliminary response data, observed by Casali (Cancer, 2004) with imatinib 800 mg/day in patients affected by chordoma, need to be confirmed by a Phase II study, whose primary endpoint will be the formal assessment of clinical and pathological response. Aim of the study will be to explore treatment's activity, but also the potential impact of tumor response, the feasibility and outcome of subsequent surgery and radiotherapy. In addition, patterns of tumour response need to be investigated as well, given the peculiar patterns of response shown with molecular-targeted therapy in solid tumors.


    status: completed
    conditions: Chordoma
    interventions: imatinib
    phase: Phase 2
    study type: Interventional
    study design: Treatment, Non-Randomized, Open Label, Uncontrolled, Single Group Assignment
    official title: Phase II Study of Imatinib Mesylate in Chordoma

  • Further study details (as provided by Novartis)

    primary outcome measures:

    • tumor response rate at 3-month interval [ Time Frame: every 3 months for 2 years ]

    secondary outcome measures:

    • overall survival [ Time Frame: every 3 months for 2 years ]
    • progression free survival after 24-month treatment [ Time Frame: every 3 months for 2 years ]

    enrollment: 55

    study start date: October 2004


    Arms Assigned Interventions

    imatinib: Experimental

    Drug: imatinib

  • Eligibility

    ages eligible for study:
    genders eligible for study: Both

    Criteria

    Inclusion Criteria:
    1. Histological diagnosis of chordoma.
    2. Biomolecular or immunohistochemical evidence of Imatinib mesylate target (PDGFRβ
    activation and/or presence of PDGFB). Biomolecular assessment of PDGFRβ activation should be made whenever possible. To this end, if frozen material is not available, obtaining of, fresh material is encouraged, if it should be obtained with no major distress for the patient, preferably through an incisional biopsy (to allow immunoprecipitation) or, if this is not feasible, a Trucut biopsy (to allow Western Blot assessment). However, if frozen or fresh material cannot be obtained, paraffined material is also acceptable. The biomolecular assessment will be centralized to the reference centers (to be defined).
    3. Measurable or evaluable disease
    4. Surgical resection of local disease unfeasible radically, or unaccepted by the
    patient, or amenable to become less demolitive, or easier, or likely more feasible, after cytoreduction, and/or metastatic disease.
    Debulking surgery before enrolment is allowed. In this case, enrolment should occur at least one month after surgery 5. Performance status 0, 1, 2 or 3 (ECOG) (see § 8.1).
    6. Adequate end organ function, defined as the following: total bilirubin <1.5 x ULN,
    SGOT and SGPT <2.5 x UNL (or <5 x ULN if hepatic metastases are present), creatinine <1.5 x ULN.
    7. Adequate bone marrow function, defined as the following: ANC >1.5 x 10^9/L, platelets
    >100 x 10^9/L, Hb >9 g/dL. Blood transfusions are allowed to reach the baseline requested Hb level.
    8. Female patients of child-bearing potential must have negative pregnancy test within 7
    days before initiation of study drug dosing. Post menopausal women must be amenorrheic for at least 12 months to be considered of non-childbearing potential.
    Male and female patients of reproductive potential must agree to employ an effective method of birth control throughout the study and for up to 3 months following discontinuation of study drug.
    9. Written, voluntary, informed consent.

    Exclusion Criteria:
    1. Previous treatment with any other investigational or not investigational agents
    within 28 days of first day of study drug dosing.
    2. Other primary malignancy with <5 years clinically assessed disease-free interval,
    except basal cell skin cancer, cervical carcinoma in situ, or other neoplasms judged to entail a low risk of relapse.
    3. Grade III/IV cardiac problems as defined by the New York Heart Association Criteria
    (i.e., congestive heart failure, myocardial infarction within 6 months of study) 4. Severe and/or uncontrolled medical disease (i.e., uncontrolled diabetes, chronic
    renal disease, or active uncontrolled infection).
    5. Known brain metastasis.
    6. Known chronic liver disease (i.e., chronic active hepatitis, and cirrhosis).
    7. Known diagnosis of human immunodeficiency virus (HIV) infection.
    8. Previous radiotherapy to >=25 % of the bone marrow.
    9. Major surgery within 2 weeks prior to study entry.
    10. Expected non-compliance to medical regimens.

  • Contacts and locations

    Please refer to this study by its ClinicalTrials.gov identifier: NCT00150072

    Locations

    Italy  - Novartis Investigative Site

    facility: Milano, Italy

  • Sponsors and collaborators

    Novartis Pharmaceuticals

    investigators: Novartis Pharmaceuticals, Study Director, Novartis Pharmaceuticals

  • More information

    Visit NovartisClinicalTrials.com: Pre-qualify for a trial, and view a list of trials and participating study centers.

    first received: September 7, 2005
    last updated: September 22, 2009
    ClinicalTrials.gov Identifier: NCT00150072
    health authority: Italy: National Monitoring Centre for Clinical Trials - Ministry of Health

Information obtained from ClinicalTrials.gov on September 25, 2009   Link to the current ClinicalTrials.gov record.

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