1 to 10 of 392 studies

• GSK cancer cell line transcript profiling

  Homo sapiens |   RNA Expression

  Genome-wide microarray studies performed in triplicate to measure the transcript profile of various cancer cell lines. This data set was generated and provided by GlaxoSmithKline.

  Source: NextBio Library/Oncology

  Total # Biosets: 315

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• Cancer census - gene mutations in cancer and other diseases

  Homo sapiens |   Mutations/Phenotypic

  The Cancer Gene Census is an ongoing effort to catalogue those genes for which mutations have been causally implicated in cancer. The original census and analysis was published in Nature Reviews Cancer

  Authors: P Andrew Futreal, Lachlan Coin, Mhairi Marshall, Thomas Down, Timothy Hubbard, Richard Wooster et al.

  Organization: Cancer Genome Project, Human Genome Analysis Group and Pfam Group, Wellcome Trust Sanger Institute

  Total # Biosets: 226

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• GNF Body Atlas Hs: Relative gene expression

  Homo sapiens |   RNA Expression

  The tissue-specific pattern of mRNA expression can indicate important clues about gene function. High-density oligonucleotide arrays offer the opportunity to examine patterns of gene expression on a genome scale. Toward this end, we have designed custom arrays that interrogate the expression of the …

  Authors: Su AI, Wiltshire T, Batalov S, Lapp H, Ching KA, Block D et al.

  Organization: Genomics Institute of the Novartis Research Foundation RNA Profiling Group 10675 John Jay Hopkins San Diego CA 92121 Country USA

  Total # Biosets: 78

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• OMIM - Malignant neoplasms

  Homo sapiens |   Mutations/Phenotypic

  This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories.

  Source: NextBio Library/Mutation and Phenotypic data

  Total # Biosets: 70

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• Gene expression-based high-throughput screening in leukemia

  Homo sapiens |   RNA Expression

  We developed a general approach to small molecule library screening called GE-HTS (Gene Expression-Based High Throughput Screening) in which a gene expression signature is used as a surrogate for cellular states and applied it to the identification of compounds inducing the differentiation of acute …

  Authors: Stegmaier K, Ross KN, Colavito SA, O'Malley S, Stockwell BR, Golub TR et al.

  Organization: Broad Institute Cancer Genomics Golub Lab 320 Charles Cambridge MA 02141 Country USA

  Total # Biosets: 20

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• Bone marrow cells from myelodysplastic syndrome patient

  Homo sapiens |   RNA Expression

  Bone marrow cells from the MDS patients were sorted into blastic, myeloid, erythroid and lymphoid fractions by flow cytometry and then were profiled transcriptionally.

  Source: NextBio Library/Immune response and infection

  Total # Biosets: 4

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• Proto-oncogene induced leukaemogenesis

  Mus musculus |   RNA Expression

  Nuclear receptor-binding SET domain protein 1 (NSD1) prototype is a family of mammalian histone methyltransferases (NSD1, NSD2/MMSET/WHSC1, NSD3/WHSC1L1) that are essential in development and are mutated in human acute myeloid leukemia (AML), overgrowth syndromes, multiple myeloma and lung cancers. …

  Authors: Wang GG, Cai L, Pasillas MP, Kamps MP.

  Organization: University of California, San Diego Pathology 9500 Gilman Drive La Jolla CA 92093 Country USA

  Total # Biosets: 1

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• Gene expression of CML CD34+ cells during imatinib therapy

  Homo sapiens |   RNA Expression

  Imatinib has become the current standard therapy for patients with chronic myelogenous leukaemia (CML). For a better understanding of the Imatinib-related molecular effects in vivo, we assessed gene expression profiles of Philadelphia Chromosome positive (Ph+) CD34+ cells from peripheral blood of 6 …

  Authors: Bruennert DC, Czibere A, Bruns I, Kronenwett R, Gattermann N, Haas R et al.

  Organization: University Clinic Duesseldorf Clinic for Hematology, Oncology and clin. Immunology Haematologisches Forschungslabor Universitaetsstr. 1 Duesseldorf 40225 Country Germany

  Total # Biosets: 1

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• RNA degradation and apoptosis from purification and valproic acid treatment in PBMCs and NB4 cells

  Homo sapiens |   RNA Expression

  RNA degradation and apoptosis studies in PMBCs and NB 4 cells

  Authors: Auer Herbert, Lyianarachchi Sandya, Newsom David, Klisovic I Marko, Marcucci Guido, Kornacker Karl et al.

  Organization: Human Cancer Genetics 420 West 12th Ave Columbus OH 43210 Country USA

  Total # Biosets: 5

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• APL subtype M3 expression compared to other subtypes and normal promyelocytes

  Homo sapiens |   RNA Expression

  To better understand the pathogenesis of acute promyelocytic leukemia (APL, FAB M3 AML), we identified genes that are expressed differently in APL cells compared to other acute myeloid leukemia subtypes, and to normal promyelocytes.

  Authors: Payton E Jacqueline, Grieselhuber Nicole, Ley J Timothy

  Organization: Washington University School of Medicine 4320 Forest Park Avenue, Suite 211 St Louis MO 63108 Country USA

  Total # Biosets: 14

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