1 to 10 of 51 studies

• OMIM - Congenital disorder

  Homo sapiens

  This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories.

  Source: NextBio Library/Mutation and Phenotypic data

  Total # Biosets: 614

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• Gene expression in neuroblastomas with recurrent genomic alterations

  Homo sapiens

  Gene expression analysis was performed on 30 Neuroblastomas to identify genes whose transcription is significantly altered by recurrent chromosomal alterations.

  Authors: Jackson S Michael, Lastowska Maria

  Organization: Newcastle University Institute of Human Genetics Central Parkway Newcastle upon Tyne NE1 3BZ Country United Kingdom

  Total # Biosets: 9

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• WNT/Beta-Catenin or WT1 target genes

  Homo sapiens

  To ask whether stabilization of beta-catenin might be essential after WT1 loss, and to identify downstream target genes, we compared expression profiles in WT1-mutant versus WT1 wild-type Wilms' tumors.

  Authors: Tycko B, Li C, Margolin AA

  Organization: Columbia University ICG Tycko Lab 1130 St Nicholas Ave, rm607 New York NY 10032 Country USA

  Total # Biosets: 5

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• OMIM - Unspecified immunity deficiency

  Homo sapiens

  This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories.

  Source: NextBio Library/Mutation and Phenotypic data

  Total # Biosets: 33

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• Human embryonic kidney cells overexpressing SMYD2

  Homo sapiens

  The objective of this aim is to identify which genes are regulated by SMYD2 through its histone lysine methylation activity

  Source: NextBio Library/Metabolic disorders and Obesity

  Total # Biosets: 1

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• Inversions with breakpoints near testis expressed genes compared to their progenitors

  D. melanogaster

  Inversions were generated in D. melanogaster chromosomes near testis expressed genes. 12 different inversion stocks, including stock carrying two inversions, 3 or 4 biological replicates for each, including dye swaps

  Source: NextBio Library/Stem Cells, Differentiation & Development

  Total # Biosets: 12

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• Gene Expression in MEFs Trisomic for Chromosomes 1, 13, 16 and 19

  Mus musculus

  Expression profile of mouse embryo fibroblast (MEF) line with a normal complement of chromosomes was compared to MEF lines with three copies of chromosome 1, chromosome 13, chromosome 16 and chromosome 19 respectively.

  Authors: Williams BR, Prabhu VR, Hunter KE, Glazier CM, Whittaker CA, Housman DE et al.

  Organization: Koch Institute 77 Mass Ave E18-366 Cambridge MA 02152 Country USA

  Total # Biosets: 9

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• POU5F1/Oct-4/3 overexpressing human cells

  Homo sapiens

  To investigate whether cells of mesenchymal origin acquire embryonic phenotype, we generated a human cell line of mesodermal origin with overexpression of the chimeric POU5F1 gene with physiological co-activator EWS, which is driven by the potent EWS promoter by translocation. The cell line termed P…

  Organization: National Research Institute for Child Health and Development Reproductive Biology 2-10-1 Okura Setagaya-ku Tokyo 157-8535 Country Japan

  Total # Biosets: 5

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• Transchromosomic mouse embryos carrying freely segregating Hsa21

  Homo sapiens

  Transcription profiling of expressed human chromosome 21 genes in transchromosomic mouse embryos carrying a freely segregating copy of Hsa21

  Source: NextBio Library/Neurological disorders

  Total # Biosets: 1

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• Human embryonic stem cells vs carcinoma cells

  Homo sapiens

  Recent reports indicated that during long term culture HESCs acquired cytogenetic abnormality which are similar to those occurred in tumorigenesis. This raise concerns about the safety use of cultured HESCs. The cause of genetical instability in cultured HESCs is poorly understood and whether these …

  Authors: Sheng Y, Lin G, Luo S, Zhou D, Deng L, Liu T et al.

  Organization: Institute of Human Reproduction & Stem Cell Engineering, Central South University xiangya Road changsha 410078 Country China

  Total # Biosets: 1

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