1 to 10 of 1,208 studies

• Drug target sets for approved compounds

  score: 100 | Homo sapiens |   Therapeutic

  The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.

  Authors: David S Wishart, Craig Knox, An Chi Guo, Dean Cheng, Savita Shrivastava, Dan Tzur et al.

  Organization: Department of Computing Science, University of Alberta

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• OMIM - Hyperlipidemia

  score: 100 | Homo sapiens |   Mutations/Phenotypic

  This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories.

  Source: NextBio Library/Mutation and Phenotypic data

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• Liver Pharmacology and Xenobiotic Response Repertoire

  score: 100 | Rattus norvegicus |   RNA Expression

  A definition of RNA expression changes that correlate with liver response programs and an understanding of the similarities and differences in responses to different classes of chemicals would aid in new chemical or drug characterization and add to our understanding of liver biology.

  Authors: Natsoulis G, Pearson CI, Gollub J, Eynon B, Ferng J, Nair R et al.

  Organization: Iconix Biosciences 325 E. Middlefield Rd. Mountain View CA 94043 USA

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• Liver transcriptional response to tumorigenic triazole conazoles exposure

  score: 99 | Mus musculus |   RNA Expression

  Transcriptional analyses of hepatic tissue from mice exposed to Phenobarbital, propiconazole or triadimefon at tumorigenic exposure levels.

  Source: NextBio Library/Pharmacology and Toxicology

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• B virus and HSV-1 infected human foreskin fibroblast expression profiles

  score: 99 | Homo sapiens |   RNA Expression

  Gene expression in foreskin fibroblasts after B virus (E2490) and HSV-1 (MacIntyre) infection at 1h, 3h, and 5h.

  Source: NextBio Library/Immune response and infection

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• Neuroblastoma tumor progression transcriptome in TH-MYCN transgenic mice

  score: 99 | Mus musculus |   RNA Expression

  Cancer studies relying on analysis of diagnostic biopsies may not fully identify the molecular events associated with tumor progression. We hypothesized that characterizing the tumor progression transcriptome in TH-MYCN transgenic neuroblastoma mice would identify oncogenic drivers.

  Source: NextBio Library/Oncology

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• Impaired heart function in Apelin gene-deficient mice

  score: 99 | Mus musculus |   RNA Expression

  The endogenous peptide Apelin is crucial for maintaining heart function in pressure overload and aging

  Authors: Arab Sara, Zhang Liyong, Liu Peter, Kuba Keiji, Penninger Josef

  Organization: Toronto General Hospital/UHN cardiology Peter Liu 101 College, MaRs 3-917 Toronto ONT M5G 1L7 Country Canada

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• Breast cancer cell lines treated with doxorubicin and p53-RNAi

  score: 98 | Homo sapiens |   RNA Expression

  p53-dependent gene expression signatures of four cell lines (MCF-7, ZR-75-1, and two immortalized human mammary epithelial cell lines) were identified by comparing p53-RNAi transduced cell lines to their parent cell lines.

  Organization: University of North Carolina at Chapel Hill CB#7295 102 Mason Farm Road Chapel Hill NC 27599-7295 Country USA

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• HeLa cells with RNAi targetting A1 hnRNP, FUS, H hnRNP and p68-DDX5

  score: 98 | Homo sapiens |   RNA Expression

  Four different RNA interference targets were compared in HeLa cells: A1 hnRNP (HNRNPA1, Heterogeneous nuclear ribonucleoprotein A1); FUS (fusion gene, involved in t(12;16) in malignant liposarcoma); H hnRNP (HNRNPH1); and p68 helicase (DDX5, DEAD (Asp-Glu-Ala-Asp) box polypeptide 5).

  Authors: Camats M, Guil S, Kokolo M, Bach-Elias M

  Organization: CRG Passeig Maritim 37-49 Barcelona 08003 Country Spain

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• Mus musculus subspecies and their F1 hybrids

  score: 98 | Mus musculus |   RNA Expression

  We have studied different subspecies of the house mouse (M. m. musculus, M. m. domesticus and M. m. castaneus) and their reciprocal F1 hybrids to estimate the within-locus mode of inheritance for subspecies differences in gene expression in three tissues (brain, liver, testis) of male mice. This stu…

  Authors: Rottscheidt Ruth, Harr Bettina

  Organization: University of Cologne Institute for Genetics Tautz Harr Mouse Evolutionary Genomics Zuelpicher Strasse 47 Cologne 50674 Country Germany

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