1 to 10 of 83 studies

• Hepatocellular Carcinoma Grade and Iron Homeostasis

  Homo sapiens |   RNA Expression

  To improve the clinical management of human hepatocellular carcinoma (HCC) by accurate identification, at diagnosis, of patients at risk of recurrence after primary treatment for HCC

  Authors: Suk Mei Wang, London Lucien P J Ooi, Kam M Hui

  Organization: Bek Chai Heah Laboratory of Cancer Genomics, Division of Cellular and Molecular Research, Humphrey Oei Institute of Cancer Research

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• Genome wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma

  Homo sapiens |   RNA Expression

  Gene expression profiles of 75 tissue samples were analyzed representing the stepwise carcinogenic process from pre-neoplastic lesions (cirrhosis and dysplasia) to HCC, including four neoplastic stages (very early HCC to metastatic tumors) from patients with HCV infection. Gene signatures that accur…

  Authors: Wurmbach E, Chen Y, Khitrov G, Zhang W, Roayaie S, Schwartz M et al.

  Organization: Mount Sinai School of Medicine Hematology/Oncology Sam Waxman 1 Gustave L. Levy Place New York NY 10029 Country USA

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• HNF1-alpha inactivation in hepatocellular adenoma

  Homo sapiens |   RNA Expression

  Biallelic inactivating mutations of the transcription factor 1 gene (TCF1), encoding hepatocyte nuclear factor 1a (HNF1a), were identified in 50% of hepatocellular adenomas (HCA) phenotypically characterized by a striking steatosis. To understand the molecular basis of this aberrant lipid storage, w…

  Authors: Rebouissou S, Imbeaud S, Balabaud C, Boulanger V, Bertrand-Michel J, Tercé F et al.

  Organization: CNRS UMR7091 Array s/IMAGE, Genexpress Functional Genomics and System Biology for Health 7 rue Guy Moquet, BP8 Villejuif Cedex 94801 Country France

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• Antiviral therapies peginterferon against hepatitis C

  Homo sapiens |   RNA Expression

  Time series of gene expression arrays before and during treatment of Hepatitis C; days 0, 1, 2, 7, 14 and 28 for 69 participants (IDs 1 through 69 are used).

  Authors: Taylor W Milton, Tsukahara Takuma, Brodsky Leonid, Schaley Joel, Sanda Corneliu, Stephens J Matthew et al.

  Organization: Indiana University Biology 343 Jordan Hall Bloomington IN 47405 Country USA

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• Human Hepatocellular Carcinoma study

  Homo sapiens |   RNA Expression

  Global gene expression patterns of 91 human hepatocellular carcinomas (HCC) were analyzed to define the molecular characteristics of the tumors and to test the prognostic value of the expression profiles. Total RNAs were isolated from frozen liver tissue using CsCl density gradient centrifugation me…

  Authors: Lee Ju-Seog, Chu S I, Heo J, Calvisi F D, Sun Z, Roskams T et al.

  Organization: National Cancer institute/NIH Laboratory of Experimental Carcinogenesis Cellular and Molecular Biology Section 37 Convent Dr. # 4146 Bethesda MD 20892 Country USA

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• HepG2 human liver cell line transfected with Hepatitis C Core protein

  Homo sapiens |   RNA Expression

  Hepatitis C virus (HCV) Core protein is implicated in the development of hepatocellular carcinoma (HCC). We utilized a HepG2 human hepatocyte cell line with inducible expression of HCV Core protein (HCV-1b) to investigate the early effects of Core protein on hepatocyte gene expression and to identif…

  Authors: George Michael, Nguyen Hau, Dandekar Satya

  Organization: University of California, Davis Microarray Core Facility School of Medicine One Shields Ave Davis CA 95616 Country USA

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• HEK293 cells overexpressing WT HNF4a2 or mutants HNF4a2 C106R or HNF4a2 R154X

  Homo sapiens |   RNA Expression

  Analysis of gene expression in human embryonic kidney cells HEK293 overexpressing the transcription factors HNF4a2 or mutant forms HNF4a2 C106R and HNF4a2 R154X, which were introduced by FRT/FLP recombination. The analysis was performed 24 hours following 1 µg/ml tetracycline treatment to induce the…

  Authors: Lucas Belen, Grigo Karen, Erdmann Silke, Lausen Jörn, Klein-Hitpass Ludger, Ryffel U Gerhart

  Organization: Institut fuer Zellbiologie Universitaetsklinikum BioChip Lab Virchowstr. 173 Essen D-45122 Country Germany

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• Gene Expression Profiling of Hepatocellular Carcinoma

  Homo sapiens |   RNA Expression

  To identify the prognostic subtypes of hepatocellular carcinoma with potential progenitor cell origin.

  Organization: NCI LHC 37 Convent Dr Bethesda MD 20892 Country USA

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• Triazole Antifungal Toxicogenomics in Primary Hepatocytes

  Homo sapiens |   RNA Expression

  The triazole antifungals myclobutanil (MYC), propiconazole (PPZ) and triadimefon (TDF) [Propiconazole CASNR 60207-90-1; Triadimefon CASNR 43121-43-3; Myclobutanil CASNR 88671-89-0] all disrupt steroid hormone homeostasis and cause varying degrees of hepatic toxicity. To identify biological pathways …

  Authors: Dix J David, Goetz K Amber

  Organization: US EPA ORD/NCCT 109 TW Alexander Drive Research Triangle Park NC 27711 Country USA

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• Liver metastasis gene signatures in colorectal cancer

  Homo sapiens |   RNA Expression

  Liver metastasis is one of the major causes of death in the patients with colorectal cancer (CRC). By using a cDNA microarray, we have identified potentially metastasis-specific genes from the colorectal cancer patients. We scanned the whole human genome using a cDNA microarray and identified 46 gen…

  Authors: KI DONGHYUK, CHUNG HYUNCHUL, PARK CHANHEE, KANG SEUNGHEE, LEE GUIYOUN, KIM NAMKYU et al.

  Organization: NBRC sinchon-dong 134 Seoul 120-752 Country Korea

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