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Results presented below are derived from NCBI GEO, EBI ArrayExpress, Broad Institute CMAP 2.0, OMIM and Jackson Laboratory's Mouse Genome Database, as well as additional sources of high-throughput data. High-throughput data retrieved from these sources is curated and processed by NextBio scientists. The results meeting pre-defined significance criteria are imported, and then correlated to all existing study results using NextBio's correlation engine. Green bars viewable under the categories tabs represent the significance of each result's association with the initial concept searched.


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Fenofibrate related studies

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1 to 9 of 9 studies

  • Drug-Induced Renal Tubular Toxicity

    Rattus norvegicus Rattus norvegicus | RNA Expression   RNA Expression

    These data support the publication titled "A Gene Expression Signature that Predicts the Future Onset of Drug-Induced Renal Tubular Toxicity"

    Authors: Fielden MR, Eynon BP, Natsoulis G, Jarnagin K, Banas D, Kolaja KL

    Organization: Iconix Pharmaceuticals 325 E Middlefield Rd Mountain View CA 94043 Country USA

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  • Non-genotoxic Hepatocarcinogens (Iconix study)

    Rattus norvegicus Rattus norvegicus | RNA Expression   RNA Expression

    We have developed a short-term in vivo rat assay that predicts whether non-genotoxic chemicals are likely to induce hepatic tumors based on transcript profiles in the liver. Using a large independent test set, assay accuracy was found to be superior to existing pathological and genomic markers. Comp…

    Authors: Fielden MR, Brennan R, Gollub J

    Organization: Iconix Biosciences 325 E. Middlefield Rd. Mountain View CA 94043 Country USA

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  • Skeletal muscle (type1 and 2 fibers) and liver gene expression induced by PPARa agonists

    Rattus norvegicus Rattus norvegicus | RNA Expression   RNA Expression

    To characterize the transcriptional effects of PPARa on skeletal muscle, researchers investigated gene expression in rat skeletal muscle and liver in response to oral gavage of 5 different PPARa agonists (fenofibrate, bezafibrate, pirinixic acid, retinoic acid, and rosiglitazone). Researchers compa…

    Organization: Rosetta Inpharmatics Informatics 401 Terry Ave N Seattle WA 98109 Country USA

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  • Drug target sets for approved compounds

    Homo sapiens Homo sapiens | Therapeutic   Therapeutic

    The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.

    Authors: David S Wishart, Craig Knox, An Chi Guo, Dean Cheng, Savita Shrivastava, Dan Tzur et al.

    Organization: Department of Computing Science, University of Alberta

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  • Broad Connectivity Map (CMAP 2.0) compound database

    Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    A reference collection of genome-wide transcriptional expression data from cultured human cells treated with bioactive small molecules that enable the discovery of functional connections between drugs, genes and diseases through the transitory feature of common gene-expression changes.

    Authors: Lamb J

    Organization: Broad Institute Seven Cambridge Center Cambridge MA 02142 USA

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  • Effect of synthetic dietary triglycerides on liver of WT and PPARĪ±-null mice

    Mus musculus Mus musculus | RNA Expression   RNA Expression

    However, the relative importance of these transcription factors in regulation of gene expression by dietary fatty acids remains unclear. Here, we take advantage of a unique experimental design using synthetic triglycerides composed of one single fatty acid in combination with gene expression profili…

    Authors: Sanderson LM, de Groot PJ, Hooiveld GJ, Muller M, Kersten S

    Organization: Wageningen University Div. Human Nutrition Nutrition, Metabolism & Genomics Group Bomenweg 2 Wageningen NL-6703HD Country Netherlands

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  • Diverse liver drug signatures

    Rattus norvegicus Rattus norvegicus | RNA Expression   RNA Expression

    These data support the publication titled "Classification of a large micro-array dataset. Algorithm comparison and analysis of drug signatures".

    Authors: Natsoulis Georges, El Ghaoui Laurent, Lanckriet R Gert, Tolley M Alexander, Leroy Fabrice, Dunlea Shane et al.

    Organization: Iconix Biosciences 325 East Middlefield Road Mountain View CA 94043 Country USA

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  • Expression profile of HUVECs treated with fenofibrate

    Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    Gene expression time series of human endothelial cells treated with fenofibrate.

    Source: NextBio Library/Pharmacology and Toxicology

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  • Liver Pharmacology and Xenobiotic Response Repertoire

    Rattus norvegicus Rattus norvegicus | RNA Expression   RNA Expression

    A definition of RNA expression changes that correlate with liver response programs and an understanding of the similarities and differences in responses to different classes of chemicals would aid in new chemical or drug characterization and add to our understanding of liver biology.

    Authors: Natsoulis G, Pearson CI, Gollub J, Eynon B, Ferng J, Nair R et al.

    Organization: Iconix Biosciences 325 E. Middlefield Rd. Mountain View CA 94043 USA

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