10 studies

• Drug-Induced Renal Tubular Toxicity

  Rattus norvegicus |   RNA Expression

  These data support the publication titled "A Gene Expression Signature that Predicts the Future Onset of Drug-Induced Renal Tubular Toxicity"

  Authors: Fielden MR, Eynon BP, Natsoulis G, Jarnagin K, Banas D, Kolaja KL

  Organization: Iconix Pharmaceuticals 325 E Middlefield Rd Mountain View CA 94043 Country USA

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• Rat liver response to Clofibrate,Valproate and Diethylhexyl phthalate

  Rattus norvegicus |   RNA Expression

  The project had 2 goals: 1) To evaluate the transcriptional response of 3 prototypical toxicants (Clofibrate, VPA, and DEHP) on rat lever. 2) To evaluate the impact pooling samples has on data analysis.

  Authors: Jolly RA, Goldstein KM, Wei T, Gao H, Chen P, Huang S et al.

  Organization: Eli Lilly & Co. Integrative Biology 2001 West Main st (US-40) Greenfield IN 46140 Country USA

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• Non-genotoxic Hepatocarcinogens (Iconix study)

  Rattus norvegicus |   RNA Expression

  We have developed a short-term in vivo rat assay that predicts whether non-genotoxic chemicals are likely to induce hepatic tumors based on transcript profiles in the liver. Using a large independent test set, assay accuracy was found to be superior to existing pathological and genomic markers. Comp…

  Authors: Fielden MR, Brennan R, Gollub J

  Organization: Iconix Biosciences 325 E. Middlefield Rd. Mountain View CA 94043 Country USA

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• Drug target sets for approved compounds

  Homo sapiens |   Therapeutic

  The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.

  Authors: David S Wishart, Craig Knox, An Chi Guo, Dean Cheng, Savita Shrivastava, Dan Tzur et al.

  Organization: Department of Computing Science, University of Alberta

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• Time-course of rat liver response to prototypical toxicants

  Rattus norvegicus |   RNA Expression

  Transcription profiling of rat liver pooled vs. individual samplesf rom a single-dose time-course rat study in response to the prototypical toxicants Clofibrate, Diethylhexyl phthalate, and valproic acid,

  Source: NextBio Library/Pharmacology and Toxicology

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• Broad Connectivity Map (CMAP 2.0) compound database

  Homo sapiens |   RNA Expression

  A reference collection of genome-wide transcriptional expression data from cultured human cells treated with bioactive small molecules that enable the discovery of functional connections between drugs, genes and diseases through the transitory feature of common gene-expression changes.

  Authors: Lamb J

  Organization: Broad Institute Seven Cambridge Center Cambridge MA 02142 USA

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• Effects of atrazine, clofibrate, fluoranthen or beta naphthoflavone on C. elegans

  C. elegans |   RNA Expression

  Using a C. elegans whole genome DNA microarray in this study, the effects of different xenobiotics on the gene expression of the nematode were investigated.

  Authors: Menzel Ralph

  Organization: Stanford Microarray Database (SMD) Stanford University, School of Medicine 300 Pasteur Drive Stanford CA 94305 Country USA

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• Diverse liver drug signatures

  Rattus norvegicus |   RNA Expression

  These data support the publication titled "Classification of a large micro-array dataset. Algorithm comparison and analysis of drug signatures".

  Authors: Natsoulis Georges, El Ghaoui Laurent, Lanckriet R Gert, Tolley M Alexander, Leroy Fabrice, Dunlea Shane et al.

  Organization: Iconix Biosciences 325 East Middlefield Road Mountain View CA 94043 Country USA

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• Liver Pharmacology and Xenobiotic Response Repertoire

  Rattus norvegicus |   RNA Expression

  A definition of RNA expression changes that correlate with liver response programs and an understanding of the similarities and differences in responses to different classes of chemicals would aid in new chemical or drug characterization and add to our understanding of liver biology.

  Authors: Natsoulis G, Pearson CI, Gollub J, Eynon B, Ferng J, Nair R et al.

  Organization: Iconix Biosciences 325 E. Middlefield Rd. Mountain View CA 94043 USA

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• Identification of biomarkers distinguishing chemical contaminants using rat hepatocytes

  Rattus norvegicus |   RNA Expression

  Here we investigate the use of microarrays to predict chemical contaminants and their possible mechanisms. Primary cultured rat hepatocytes were treated with one of 105 compounds with relative controls.

  Source: NextBio Library/Pharmacology and Toxicology

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